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Xiaojing Sui
Researcher at University of Melbourne
Publications - 19
Citations - 592
Xiaojing Sui is an academic researcher from University of Melbourne. The author has contributed to research in topics: Proteome & Proteostasis. The author has an hindex of 12, co-authored 16 publications receiving 487 citations. Previous affiliations of Xiaojing Sui include Chinese Academy of Sciences & Shenzhen University.
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Journal ArticleDOI
Cerebrospinal fluid biomarkers of Alzheimer's disease.
TL;DR: The metabolism and diagnostic performance of the well-established core candidate cerebrospinal fluid biomarkers (β-amyloid, total tau, and hyperphosphorylated tau) are discussed and novel promising CSF biomarkers, especially those identified by proteomics, updated in the last five years are also extensively discussed.
Journal ArticleDOI
Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.
Yasmin M. Ramdzan,Mikhail M. Trubetskov,Angelique R. Ormsby,Estella A. Newcombe,Xiaojing Sui,Mark J. Tobin,Marie N. Bongiovanni,Sally L. Gras,Grant Dewson,Grant Dewson,Jason Miller,Steven Finkbeiner,Nagaraj S. Moily,Jonathan C. Niclis,Clare L. Parish,Anthony W. Purcell,Michael J. Baker,Jacqueline A. Wilce,Saboora Waris,Diana Stojanovski,Till Böcking,Ching-Seng Ang,David B. Ascher,Gavin E. Reid,Danny M. Hatters +24 more
TL;DR: A revised model is proposed where sequestration of soluble Httex1 inclusions can remove the trigger for apoptosis but also co-aggregate other proteins, which curtails cellular metabolism and leads to a slow death by necrosis.
Journal ArticleDOI
Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells.
Xifei Yang,Chune He,Jie Li,Hongbin Chen,Quan Ma,Xiaojing Sui,Shengli Tian,Ming Ying,Qian Zhang,Yougen Luo,Zhixiong Zhuang,Jianjun Liu +11 more
TL;DR: This is the first study with direct evidence indicating that in addition to neurotoxicity induced bySiNPs, the application of SiNPs might increase the risk of developing AD.
Journal ArticleDOI
Hypoxia-Induced Tau Phosphorylation and Memory Deficit in Rats
Chang-E Zhang,Xifei Yang,Lingyun Li,Xiaojing Sui,Qing Tian,Wei Wei,Jian-Zhi Wang,Gong-Ping Liu +7 more
TL;DR: It is demonstrated that hypoxia induced tau hyperphosphorylation and memory impairment in rats, and that the increased tau phosphorylation could be attributed to activation of GSK-3β and inactivation of PP2A.
Journal ArticleDOI
Hydrogen sulfide prevents hypoxia-induced apoptosis via inhibition of an H2O2-activated calcium signaling pathway in mouse hippocampal neurons.
Yougen Luo,Xiaoai Liu,Qisheng Zheng,Xiaomei Wan,Shuichang Ouyang,Yedong Yin,Xiaojing Sui,Jianjun Liu,Xifei Yang +8 more
TL;DR: It is suggested that H(2)S inhibits hypoxia-induced apoptosis through inhibition of a ROS-activated Ca(2+) signaling pathway in mouse hippocampal neurons.