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Angelique R. Ormsby
Researcher at University of Melbourne
Publications - 23
Citations - 584
Angelique R. Ormsby is an academic researcher from University of Melbourne. The author has contributed to research in topics: Protein aggregation & Huntingtin. The author has an hindex of 11, co-authored 19 publications receiving 417 citations.
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Journal ArticleDOI
Tracking protein aggregation and mislocalization in cells with flow cytometry
Yasmin M. Ramdzan,Saskia Polling,Cheryl Chia,Ivan Hong Wee Ng,Ivan Hong Wee Ng,Angelique R. Ormsby,Nathan P. Croft,Anthony W. Purcell,Marie A. Bogoyevitch,Dominic C.H. Ng,Paul A. Gleeson,Danny M. Hatters +11 more
TL;DR: PulSA enabled high-throughput tracking of protein aggregation, translocation from the cytoplasm to the nucleus and trafficking from the plasma membrane to the Golgi as well as stress-granule formation and combined with tetracysteine-based oligomer sensors enabled further separation of cells enriched with monomers, oligomers and inclusion bodies.
Journal ArticleDOI
Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.
Yasmin M. Ramdzan,Mikhail M. Trubetskov,Angelique R. Ormsby,Estella A. Newcombe,Xiaojing Sui,Mark J. Tobin,Marie N. Bongiovanni,Sally L. Gras,Grant Dewson,Grant Dewson,Jason Miller,Steven Finkbeiner,Nagaraj S. Moily,Jonathan C. Niclis,Clare L. Parish,Anthony W. Purcell,Michael J. Baker,Jacqueline A. Wilce,Saboora Waris,Diana Stojanovski,Till Böcking,Ching-Seng Ang,David B. Ascher,Gavin E. Reid,Danny M. Hatters +24 more
TL;DR: A revised model is proposed where sequestration of soluble Httex1 inclusions can remove the trigger for apoptosis but also co-aggregate other proteins, which curtails cellular metabolism and leads to a slow death by necrosis.
Journal ArticleDOI
Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length.
Estella A. Newcombe,Kiersten M. Ruff,Ashish Sethi,Angelique R. Ormsby,Yasmin M. Ramdzan,Archa H. Fox,Anthony W. Purcell,Paul R. Gooley,Rohit V. Pappu,Danny M. Hatters +9 more
TL;DR: Structural studies of soluble Httex1 for wild-type and mutant polyQ lengths highlight plausible connections between HTtex1 structure and routes to neurotoxicity.
Journal ArticleDOI
Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src
TL;DR: A model by which dimerization of c-Src primes c- Src via Y416 phosphorylation to enable rapid potentiation of activity when Src adopts an open conformation is suggested.
Journal ArticleDOI
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.
Xiaojing Sui,Douglas E. V. Pires,Douglas E. V. Pires,Angelique R. Ormsby,Dezerae Cox,Shuai Nie,Giulia Vecchi,Michele Vendruscolo,David B. Ascher,Gavin E. Reid,Danny M. Hatters +10 more
TL;DR: The results indicate that the protein homeostasis system is organized in a modular manner and aggregation patterns were not correlated with protein folding stability (ΔG).