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Grant Dewson

Researcher at Walter and Eliza Hall Institute of Medical Research

Publications -  100
Citations -  10108

Grant Dewson is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Bcl-2 Homologous Antagonist-Killer Protein & Bcl-2-associated X protein. The author has an hindex of 42, co-authored 97 publications receiving 7613 citations. Previous affiliations of Grant Dewson include University of Melbourne & University of Leicester.

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Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but Not Bcl-2, Until Displaced by BH3-only Proteins

Simon N. Willis, +7 more
- 01 Jun 2005 - 
TL;DR: The results indicate that Bak is held in check solely by Mcl-1 and Bcl-x(L) and induces apoptosis only if freed from both, and the finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the B cl-2 family.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

James A Rickard, +59 more
- 22 May 2014 - 
TL;DR: A key function for RIPK1 is revealed in inhibiting necroptosis and, thereby, a role in limiting, not only promoting, inflammation is revealed.
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur, +38 more
- 23 Feb 2018 - 
TL;DR: This study provides a mechanistic description of mtDNA release from mitochondria during apoptosis, and suggests that mtDNA is found outside the mitochondria—and, indeed, outside the cell—in a wide range of circumstances.
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Molecular biology of Bax and Bak activation and action

D. Westphal, +3 more
- 01 Apr 2011 - 
TL;DR: How Bax and Bak change conformation and oligomerize, as well as how oligomers might form a pore is reviewed, which indicates that they first form symmetric BH3:groove dimers which can be linked via an interface between the α6-helices to form high order oligomers.