Xiaolan Yu

TL;DR: This study maps the interactions of an unbiased selection of 5026 human liver expression proteins by yeast two‐hybrid technology and establishes a human liver protein interaction network (HLPN) composed of 3484 interactions among 2582 proteins.

TL;DR: Eight avian influenza A (H5N6) viruses were isolated from live poultry markets in Sichuan and Jiangxi Provinces in China in 2014 and contained a T160A substitution in the haemagglutinin protein and an 11 aa deletion in the neuraminidase stalk, which may aid in enhancing viral affinity for human-like receptors and virulence in mammals.

TL;DR: The anti-tumor mechanism of metformin from the aspects of cell metabolism and epigenetic modifications is discussed, which will shed lights on application of met formin in clinical trials and development of anti-cancer therapy.

TL;DR: This study showed that the N-linked glycan side-chains of several recombinant proteins expressed in Pichia pastoris can be efficiently removed through either the co-fermentation of this recombinant strain with strains expressing substrates or by mixing the cell culture supernatants of the endo-β-N-acetylglucosaminidase H expressing strain withicates after fermentation.

TL;DR: The sequence of an endo-chitosanase gene from Aspergillus fumigatus was optimized based on the preferred codons of Pichia pastoris and synthesized in vitro through overlapping PCR (CSN-P), which was used for a large-scale preparation of oligosaccharides.