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Xiaoling Gao
Researcher at Shanghai Jiao Tong University
Publications - 41
Citations - 1729
Xiaoling Gao is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Drug delivery & Medicine. The author has an hindex of 18, co-authored 36 publications receiving 1246 citations.
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Journal ArticleDOI
Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery
Jianwei Guo,Xiaoling Gao,Lina Su,Lina Su,Huimin Xia,Guangzhi Gu,Zhiqing Pang,Xinguo Jiang,Lei Yao,Jun Chen,Hong-Zhuan Chen +10 more
TL;DR: The potential utility of AS1411-functionalized nanoparticles for a therapeutic application in the treatment of gliomas was demonstrated and significantly enhanced cellular association of nanoparticles in C6 glioma cells, and increased the cytotoxicity of its payload.
Journal ArticleDOI
Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras -activated glioblastoma cells via macropinocytosis
Jialin Huang,Gan Jiang,Qingxiang Song,Xiao Gu,Meng Hu,Xiaolin Wang,Huahua Song,Lepei Chen,Yingying Lin,Di Jiang,Jun Chen,Junfeng Feng,Yongming Qiu,Jiyao Jiang,Xinguo Jiang,Hong-Zhuan Chen,Xiaoling Gao +16 more
TL;DR: A biologically inspired nanostructure that can induce cancer cells to ‘drink drugs' for targeting activating transcription factor-5 (ATF5), an overexpressed anti-apoptotic transcription factor in glioblastoma and other Ras-activated cancers is created.
Journal ArticleDOI
The association of autophagy with polyethylenimine-induced cytotoxity in nephritic and hepatic cell lines
Xiaoling Gao,Lei Yao,Qiangxiang Song,Liang Zhu,Zheng Xia,Huimin Xia,Xinguo Jiang,Jun Chen,Hong-Zhuan Chen +8 more
TL;DR: It was demonstrated that besides necrosis and apoptosis, autophagy was apparently associated withPEI-induced cytotoxicity and contributed to aggravated cell damage and it's highly recommended to design PEI-based gene-carriers that could avoid the endolysosome transport pathway.
Journal ArticleDOI
Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood–Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery
Qingxiang Song,Huahua Song,Jianrong Xu,Jialin Huang,Meng Hu,Xiao Gu,Juan Chen,Gang Zheng,Hong-Zhuan Chen,Xiaoling Gao +9 more
TL;DR: Strong evidence is provided that the ApoE-based biomimetic nanocarrier could provide a promising platform for brain drug delivery toward the treatment of AD.
Journal ArticleDOI
Multi-targeting Peptide-Functionalized Nanoparticles Recognized Vasculogenic Mimicry, Tumor Neovasculature, and Glioma Cells for Enhanced Anti-glioma Therapy
Xingye Feng,Jianhui Yao,Xiaoling Gao,Yixian Jing,Ting Kang,Di Jiang,Tianze Jiang,Jingxian Feng,Qianqian Zhu,Xinguo Jiang,Jun Chen +10 more
TL;DR: Findings indicated that the multi-targeting therapy mediated by CK peptide might provide a promising way for glioblastoma therapy.