Institution
Dali University
Education•Dali, China•
About: Dali University is a education organization based out in Dali, China. It is known for research contribution in the topics: Population & Galaxy. The organization has 1954 authors who have published 1564 publications receiving 15054 citations.
Topics: Population, Galaxy, Genome, Gene, Biology
Papers published on a yearly basis
Papers
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TL;DR: It is hypothesized that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs, and highlights the necessity of preparedness for future emergence of Sars-like diseases.
Abstract: A large number of SARS-related coronaviruses (SARSr-CoV) have been detected in horseshoe bats since 2005 in different areas of China. However, these bat SARSr-CoVs show sequence differences from SARS coronavirus (SARS-CoV) in different genes (S, ORF8, ORF3, etc) and are considered unlikely to represent the direct progenitor of SARS-CoV. Herein, we report the findings of our 5-year surveillance of SARSr-CoVs in a cave inhabited by multiple species of horseshoe bats in Yunnan Province, China. The full-length genomes of 11 newly discovered SARSr-CoV strains, together with our previous findings, reveals that the SARSr-CoVs circulating in this single location are highly diverse in the S gene, ORF3 and ORF8. Importantly, strains with high genetic similarity to SARS-CoV in the hypervariable N-terminal domain (NTD) and receptor-binding domain (RBD) of the S1 gene, the ORF3 and ORF8 region, respectively, were all discovered in this cave. In addition, we report the first discovery of bat SARSr-CoVs highly similar to human SARS-CoV in ORF3b and in the split ORF8a and 8b. Moreover, SARSr-CoV strains from this cave were more closely related to SARS-CoV in the non-structural protein genes ORF1a and 1b compared with those detected elsewhere. Recombination analysis shows evidence of frequent recombination events within the S gene and around the ORF8 between these SARSr-CoVs. We hypothesize that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs. Cell entry studies demonstrated that three newly identified SARSr-CoVs with different S protein sequences are all able to use human ACE2 as the receptor, further exhibiting the close relationship between strains in this cave and SARS-CoV. This work provides new insights into the origin and evolution of SARS-CoV and highlights the necessity of preparedness for future emergence of SARS-like diseases.
801 citations
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TL;DR: The potential utility of AS1411-functionalized nanoparticles for a therapeutic application in the treatment of gliomas was demonstrated and significantly enhanced cellular association of nanoparticles in C6 glioma cells, and increased the cytotoxicity of its payload.
510 citations
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University Health Network1, University of Toronto2, Ontario Institute for Cancer Research3, Dali University4, Central China Normal University5, Vancouver Prostate Centre6, Xiamen University of Technology7, Fudan University8, Laval University9, Sunnybrook Health Sciences Centre10, Nanjing Medical University11, Netherlands Cancer Institute12, VU University Medical Center13, University of British Columbia14, Erasmus University Rotterdam15, Northeastern University (China)16
TL;DR: Ultra-deep total RNA-seq on 144 tumors with rich clinical annotation revealed a linear transcriptomic subtype associated with the aggressive intraductal carcinoma sub-histology and a fusion profile that differentiates localized from metastatic disease.
296 citations
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TL;DR: The combined experiment and DFT results reveal that tuning the interaction between ZnO and ZrO2 can be considered as another important factor for designing high performance catalysts for methanol generation from CO2.
Abstract: The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu–ZnO–ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) measurements under the activity test pressure (3 MPa) reveal that the CO2 hydrogenation to methanol on the CZZ catalysts follows the formate pathway. Density functional theory (DFT) calculations agree with the in situ DRIFTS measurements, showing that the ZnO–ZrO2 interfaces are the active sites for CO2 adsorption and conversion, while the presence of metallic Cu is also necessary to facilitate H2 dissociation and to provide hydrogen resource. The combined experiment and DFT results reveal that tuning the interaction between ZnO and ZrO2 can be considered as another important factor for designing high performance catalysts for methanol generation from CO2. Despite great efforts, the reaction mechanism of CO2 hydrogenation to methanol and the nature of the active sites on Cu–ZnO–ZrO2 (CZZ) catalysts are still under debate. Herein, the authors report the interactions among the three components in controlling the catalytic performance of CZZ catalyst for CO2 hydrogenation to methanol.
234 citations
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TL;DR: Findings reveal a risk SNP-mediated promoter-enhancer switching mechanism underlying both initiation and progression of aggressive PCa.
232 citations
Authors
Showing all 1975 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jian Li | 133 | 2863 | 87131 |
Wen-Jun Li | 58 | 857 | 19650 |
Hua Wang | 52 | 547 | 10085 |
Yun-Zhi Zhang | 36 | 103 | 4753 |
Paul A. Garber | 34 | 175 | 3575 |
Yuhong Xu | 33 | 140 | 4733 |
Xiaohe Xiao | 30 | 170 | 2486 |
De-Quan Yang | 28 | 74 | 3170 |
Hao-Fu Dai | 28 | 261 | 3314 |
Cyril C. Grueter | 26 | 108 | 2144 |
Xiao-Jiang Hao | 26 | 138 | 2521 |
Jian Li | 26 | 142 | 2217 |
Hong-Ping He | 25 | 91 | 1677 |
Baoguo Li | 25 | 105 | 2896 |
Yu Zhao | 23 | 95 | 1590 |