Gang Zheng

TL;DR: This work focuses on the design and implementation of Activatable Photosensitizer Design Considerations, a very simple and straightforward process that simplifies and automates the very labor-intensive and therefore time-heavy and expensive process of Activation Mechanism Selection.

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.

TL;DR: It is demonstrated that tumor accumulation can be mediated by high nanoparticle avidity and are weakly dependent on their plasma clearance rate, and empirical models can be used to rapidly screen novel nanomaterials for relative differences in tumor targeting without the need for animal work.

TL;DR: It is determined that nanostructured porphyrin PTT enhancers are advantageous to overcome hypoxic conditions to achieve effective ablation of solid tumors.