J
Juan Chen
Researcher at Princess Margaret Cancer Centre
Publications - 122
Citations - 7814
Juan Chen is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Photodynamic therapy & Photosensitizer. The author has an hindex of 42, co-authored 121 publications receiving 6612 citations. Previous affiliations of Juan Chen include University of Pennsylvania & University of Toronto.
Papers
More filters
Journal ArticleDOI
Activatable photosensitizers for imaging and therapy
TL;DR: This work focuses on the design and implementation of Activatable Photosensitizer Design Considerations, a very simple and straightforward process that simplifies and automates the very labor-intensive and therefore time-heavy and expensive process of Activation Mechanism Selection.
Journal ArticleDOI
Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency.
TL;DR: It is demonstrated that tumor accumulation can be mediated by high nanoparticle avidity and are weakly dependent on their plasma clearance rate, and empirical models can be used to rapidly screen novel nanomaterials for relative differences in tumor targeting without the need for animal work.
Journal ArticleDOI
Ablation of hypoxic tumors with dose-equivalent photothermal, but not photodynamic, therapy using a nanostructured porphyrin assembly.
TL;DR: It is determined that nanostructured porphyrin PTT enhancers are advantageous to overcome hypoxic conditions to achieve effective ablation of solid tumors.
Journal ArticleDOI
Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation
TL;DR: This study validates the core principle of the PMB concept that selective PDT-induced cell death can be achieved by exerting precise control of the PS's ability to produce 1O2 by responding to specific cancer-associated biomarkers, and PDT selectivity will no longer depend on how selectively the PS can be delivered to cancer cells.
Journal ArticleDOI
The dose threshold for nanoparticle tumour delivery.
Ben Ouyang,Wilson Poon,Yi-Nan Zhang,Zachary P. Lin,Benjamin R. Kingston,Anthony J. Tavares,Anthony J. Tavares,Yuwei Zhang,Juan Chen,Michael S. Valic,Abdullah Muhammad Syed,Abdullah Muhammad Syed,Presley MacMillan,Julien Couture-Senécal,Gang Zheng,Gang Zheng,Warren C. W. Chan +16 more
TL;DR: A dose threshold for improving nanoparticle tumour delivery is discovered: 1 trillion nanoparticles in mice, which enabled up to 12% tumours delivery efficiency and delivery to 93% of cells in tumours, and also improved the therapeutic efficacy of Caelyx/Doxil.