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Xiaomei Song
Researcher at University of Rochester Medical Center
Publications - 3
Citations - 1220
Xiaomei Song is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Gene silencing & Caspase 3. The author has an hindex of 3, co-authored 3 publications receiving 1152 citations.
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Journal ArticleDOI
LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms
Rashid Deane,Zhenhua Wu,Abhay P. Sagare,Judianne Davis,Shi Du Yan,Katie Hamm,Feng Xu,Margaret Parisi,Barbra LaRue,Hong Wei Hu,Patricia P. Spijkers,Huang Guo,Xiaomei Song,Peter J. Lenting,William E. Van Nostrand,Berislav V. Zlokovic +15 more
TL;DR: Low-affinity LRP/Aβ interaction and/or Aβ-induced LRP loss at the BBB mediate brain accumulation of neurotoxic Aβ in transgenic mice and patients with cerebrovascular β-amyloidosis.
Journal ArticleDOI
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
Zhenhua Wu,Huang Guo,Huang Guo,Nienwen Chow,Jan Sallstrom,Robert D. Bell,Rashid Deane,Andrew I. Brooks,Suhasini Kanagala,Anna Rubio,Abhay P. Sagare,Dong Liu,Fang Li,Don Armstrong,Don Armstrong,Thomas A. Gasiewicz,Raphael Zidovetzki,Raphael Zidovetzki,Xiaomei Song,Florence M. Hofman,Florence M. Hofman,Berislav V. Zlokovic,Berislav V. Zlokovic +22 more
TL;DR: It is shown that restoring expression of the protein it encodes, GAX, in BECs from individuals with Alzheimer disease stimulates angiogenesis, transcriptionally suppresses AFX1 forkhead transcription factor–mediated apoptosis and increases the levels of a major amyloid-β peptide (Aβ) clearance receptor, the low-density lipoprotein receptor–related protein 1 (LRP), at the blood-brain barrier.
Journal ArticleDOI
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.
Dong Liu,Tong Cheng,Huang Guo,José A. Fernández,John H. Griffin,Xiaomei Song,Berislav V. Zlokovic +6 more
TL;DR: Activated protein C (APC), a serine protease with anticoagulant, anti-inflammatory and antiapoptotic activities, blocked tPA vascular and neuronal toxicities in vitro and in vivo and may add substantially to the effectiveness of tPA therapy for stroke.