J
Judianne Davis
Researcher at University of Rhode Island
Publications - 35
Citations - 3692
Judianne Davis is an academic researcher from University of Rhode Island. The author has contributed to research in topics: Amyloid & Cerebral amyloid angiopathy. The author has an hindex of 22, co-authored 33 publications receiving 3369 citations. Previous affiliations of Judianne Davis include Stony Brook University.
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Journal ArticleDOI
Structural conversion of neurotoxic amyloid-[beta]1-42 oligomers to fibrils
Mahiuddin Ahmed,Judianne Davis,Darryl Aucoin,Takeshi Sato,Shivani Ahuja,Saburo Aimoto,James I. Elliott,William E. Van Nostrand,Steven O. Smith +8 more
TL;DR: It is shown that low-temperature and low-salt conditions can stabilize disc-shaped oligomers (pentamers) that are substantially more toxic to mouse cortical neurons than protofibrils and fibrils, and that these neurotoxic oligomers do not have the β-sheet structure characteristic of fibril.
Journal ArticleDOI
LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms
Rashid Deane,Zhenhua Wu,Abhay P. Sagare,Judianne Davis,Shi Du Yan,Katie Hamm,Feng Xu,Margaret Parisi,Barbra LaRue,Hong Wei Hu,Patricia P. Spijkers,Huang Guo,Xiaomei Song,Peter J. Lenting,William E. Van Nostrand,Berislav V. Zlokovic +15 more
TL;DR: Low-affinity LRP/Aβ interaction and/or Aβ-induced LRP loss at the BBB mediate brain accumulation of neurotoxic Aβ in transgenic mice and patients with cerebrovascular β-amyloidosis.
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Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid β-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid β-Protein Precursor
Judianne Davis,Feng Xu,Rashid Deane,Galina Romanov,Mary Lou Previti,Kelly Zeigler,Berislav V. Zlokovic,William E. Van Nostrand +7 more
TL;DR: It is shown that overexpression of human AβPP is not required for early-onset and robust accumulation of both vascular and parenchymal Aβ in mouse brain, and in vivo transport studies demonstrated that Dutch/Iowa mutant Aβ was more readily retained in the brain compared with wild-type Aβ.
Journal ArticleDOI
Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity
Ali Reza A. Ladiwala,Jeffrey Litt,Ravi S. Kane,Darryl Aucoin,Steven O. Smith,Swarnim Ranjan,Judianne Davis,William E. Van Nostrand,Peter M. Tessier +8 more
TL;DR: The results suggest that the ability of non-fibrillar Aβ oligomers to interact with and disrupt cellular membranes is linked to the degree of solvent exposure of their central and C-terminal hydrophobic peptide segments.
Journal ArticleDOI
Minocycline Reduces Microglial Activation and Improves Behavioral Deficits in a Transgenic Model of Cerebral Microvascular Amyloid
Rong Fan,Feng Xu,Mary Lou Previti,Judianne Davis,Alicia M. Grande,John K. Robinson,William E. Van Nostrand +6 more
TL;DR: It is suggested that anti-inflammatory treatment targeted for cerebral microvascular amyloid-induced microglial activation can improve cognitive deficits without altering the accumulation and distribution of Aβ.