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Xiaoqian Liu
Researcher at Chinese Academy of Sciences
Publications - 18
Citations - 310
Xiaoqian Liu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Senescence & Medicine. The author has an hindex of 6, co-authored 9 publications receiving 134 citations. Previous affiliations of Xiaoqian Liu include Capital Medical University.
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Journal ArticleDOI
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
Shijia Bi,Zunpeng Liu,Zeming Wu,Zehua Wang,Xiaoqian Liu,Si Wang,Jie Ren,Yan Yao,Weiqi Zhang,Moshi Song,Guang-Hui Liu,Jing Qu +11 more
TL;DR: It is found that SIRT7 expression declines during human mesenchymal stem cell (hMSC) aging and that Sirt7 deficiency accelerates senescence, highlighting how SIRT6 safeguards chromatin architecture to control innate immune regulation and ensure geroprotection during stem cell aging.
Journal ArticleDOI
ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
H.X. Hu,Qianzhao Ji,Moshi Song,Jie Ren,Zunpeng Liu,Zehua Wang,Xiaoqian Liu,Kaowen Yan,Jianli Hu,Jianli Hu,Yaobin Jing,Si Wang,Weiqi Zhang,Guang-Hui Liu,Jing Qu +14 more
TL;DR: Data reveal for the first time that ZKSCAN3 functions as an epigenetic modulator to maintain heterochromatin organization and thereby attenuate cellular senescence.
Journal ArticleDOI
Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells
Chen Ling,Chen Ling,Chen Ling,Zunpeng Liu,Moshi Song,Weiqi Zhang,Si Wang,Xiaoqian Liu,Shuai Ma,Shuhui Sun,Lina Fu,Qun Chu,Juan Carlos Izpisua Belmonte,Zhaoxia Wang,Jing Qu,Yun Yuan,Guang-Hui Liu +16 more
TL;DR: Using this iPSC-based disease model, this study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease.
Journal ArticleDOI
Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming.
Pengze Yan,Zunpeng Liu,Moshi Song,Zeming Wu,Wei Xu,Kuan Li,Qianzhao Ji,Si Wang,Xiaoqian Liu,Kaowen Yan,Concepcion Rodriguez Esteban,Weimin Ci,Juan Carlos Izpisua Belmonte,Wei Xie,Jie Ren,Weiqi Zhang,Qianwen Sun,Jing Qu,Guang-Hui Liu +18 more
TL;DR: A multifaceted role of R-loops in cell fate determination that may serve as an additional layer of modulation on cell fate memory and cell plasticity is suggested.
Journal ArticleDOI
Low-dose quercetin positively regulates mouse healthspan.
Lingling Geng,Zunpeng Liu,Si Wang,Shuhui Sun,Shuai Ma,Xiaoqian Liu,Piu Chan,Liang Sun,Moshi Song,Weiqi Zhang,Guang-Hui Liu,Jing Qu +11 more
TL;DR: Que is identified as a geroprotective agent that counteracts accelerated and natural aging of hMSCs at a concentration of as low as 100 nmol/L, which is 100 times lower than the concentration of Que previously used in combination with dasatinib as senolytic drugs.