Zeming Wu

TL;DR: This study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders.

TL;DR: It is found that levels of both m6A RNA methylation and the methyltransferase METTL3 were reduced in prematurely senescent human mesenchymal stem cell (hMSC) models of progeroid syndromes, and it was discovered thatMETTL3 alleviates hMSC senescence through m 6A modification-dependent stabilization of the MIS12 transcript, representing a novel epitranscriptional mechanism in premature stem cell senescences.

TL;DR: The findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2, suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly.

TL;DR: It is found that SIRT7 expression declines during human mesenchymal stem cell (hMSC) aging and that Sirt7 deficiency accelerates senescence, highlighting how SIRT6 safeguards chromatin architecture to control innate immune regulation and ensure geroprotection during stem cell aging.

TL;DR: A novel, microRNA processing-independent role in maintaining heterochromatin organization and attenuating senescence by DGCR8 is uncovered, thus representing a new therapeutic target for alleviating human aging-related disorders.