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Xiaoqiang Cai
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 11
Citations - 1055
Xiaoqiang Cai is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Progenitor cell & Mesenchyme. The author has an hindex of 11, co-authored 11 publications receiving 901 citations.
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Journal ArticleDOI
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies.
Zhe Li,Xiaoqiang Cai,Chen-Leng Cai,Jiapeng Wang,Wenyong Zhang,Bruce Petersen,Feng Chun Yang,Mingjiang Xu +7 more
TL;DR: Tet2-deficient mice recapitulate patients with myeloid malignancies, implying that Tet2 functions as a tumor suppressor to maintain hematopoietic cell homeostasis.
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Sox2 in the dermal papilla niche controls hair growth by fine-tuning Bmp signaling in differentiating hair shaft progenitors
Carlos Clavel,Laura Grisanti,Roland Zemla,Amélie Rezza,Rita Barros,Rachel Sennett,Amin R. Mazloom,Chi-Yeh Chung,Xiaoqiang Cai,Chen-Leng Cai,Larysa H. Pevny,Silvia K. Nicolis,Avi Ma'ayan,Michael Rendl +13 more
TL;DR: Using Tbx18(Cre) to target embryonic DP precursors and ablate the transcription factor Sox2 early and efficiently, it is found that DP niche expression of Sox2 controls the migration speed of differentiating hair shaft progenitors.
Journal ArticleDOI
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis
Xiaoqiang Cai,Weijia Zhang,Jun Hu,Lu Zhang,Nishat Sultana,Bingruo Wu,Weibin Cai,Bin Zhou,Chen-Leng Cai +8 more
TL;DR: The study suggests a model in which Tbx20 regulates the Wnt pathway to direct endocardial cushion maturation and valve elongation, and provides new insights into the etiology of valve defects in humans.
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Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development
Lu Zhang,Aya Nomura-Kitabayashi,Nishat Sultana,Weibin Cai,Xiaoqiang Cai,Anne M. Moon,Chen-Leng Cai +6 more
TL;DR: It is found that heart development appeared normal after endodermal deletion of Nkx2.5 whereas mesodmal deletion engendered cardiac defects almost identical to those observed on Nk X.5 null embryos (Nkx 2.5(-/-)).
Journal ArticleDOI
Tbx18 Targets Dermal Condensates for Labeling, Isolation, and Gene Ablation during Embryonic Hair Follicle Formation
Laura Grisanti,Carlos Clavel,Xiaoqiang Cai,Amélie Rezza,Su-Yi Tsai,Rachel Sennett,Melanie Mumau,Chen-Leng Cai,Michael Rendl +8 more
TL;DR: This study establishes Tbx18 as a genetic driver to target embryonic DP precursors for labeling, isolation and gene ablation that will greatly enhance investigations into their molecular functions during hair follicle morphogenesis.