Xiaotao Wang

TL;DR: A comprehensive map of transcriptomes, cis -regulatory elements, heterochromatin structure, the methylome and 3D genome organization in the zebrafish enables identification of species-specific and evolutionarily conserved regulatory features, and provides a foundation for modelling studies on human disease and development.

TL;DR: This work presents Peakachu, a Random Forest classification framework that predicts chromatin loops from genome-wide contact maps, and applies it to systematically predict Chromatin loops in 56 Hi-C datasets, with results available at the 3D Genome Browser.

TL;DR: In this paper, the authors used a novel HP1α auxin-inducible degron human cell line to rapidly degrade HP 1α (CBX5) and found that HP 1 α is essential to chromatin-based mechanics and maintains nuclear morphology.

TL;DR: NeLoopFinder as discussed by the authors is a computational framework to identify the chromatin interactions induced by structural variations, including interchromosomal translocations, large deletions and inversions, which can enable identification of critical oncogenic regulatory elements that can potentially reveal therapeutic targets.

TL;DR: This work presents Peakachu, a Random Forest classification framework that predicts chromatin loops from genome-wide contact maps with more meaningful short-range interactions, and applies this framework to systematically predict Chromatin loops in 56 Hi-C datasets.