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Xiaoxia Z. West
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 15
Citations - 1134
Xiaoxia Z. West is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Inflammation & Angiogenesis. The author has an hindex of 13, co-authored 15 publications receiving 975 citations. Previous affiliations of Xiaoxia Z. West include Case Western Reserve University & Cleveland Clinic.
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Journal ArticleDOI
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
Xiaoxia Z. West,Nikolay L. Malinin,Alona Merkulova,Mira Tischenko,Bethany A. Kerr,Ernest C. Borden,Eugene A. Podrez,Robert G. Salomon,Tatiana V. Byzova +8 more
TL;DR: These findings establish a new function of TLR2 as a sensor of oxidation-associated molecular patterns, providing a key link connecting inflammation, oxidative stress, innate immunity and angiogenesis.
Journal ArticleDOI
Inflammation and oxidative stress in angiogenesis and vascular disease
TL;DR: This review discusses the recent findings in the area bridging neovascularization and oxidation and highlights novel mechanisms of inflammation- and oxidative stress-driven angiogenesis.
Journal ArticleDOI
Engagement of Platelet Toll-Like Receptor 9 by Novel Endogenous Ligands Promotes Platelet Hyperreactivity and Thrombosis
Soumya Panigrahi,Yi Ma,Li Hong,Detao Gao,Xiaoxia Z. West,Robert G. Salomon,Tatiana V. Byzova,Eugene A. Podrez +7 more
TL;DR: It is demonstrated that platelet TLR9 is a functional platelet receptor that links oxidative stress, innate immunity, and thrombosis and carboxy(alkylpyrrole) protein adducts represent novel unconventional ligands forTLR9.
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Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
Bethany A. Kerr,Xiaoxia Z. West,Young Woong Kim,Yongzhong Zhao,Miroslava Tischenko,Rebecca M. Cull,Timothy W. Phares,Xiao Ding Peng,Jeremiah Bernier-Latmani,Tatiana V. Petrova,Ralf H. Adams,Nissim Hay,Sathyamangla V. Naga Prasad,Tatiana V. Byzova +13 more
TL;DR: Sustained endothelial Akt1/2 signalling is critical in maintaining vascular stability and homeostasis, thereby preserving tissue and organ function.
Journal ArticleDOI
The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish
Elzbieta Pluskota,James J. Dowling,Natalie Gordon,Jeffrey A. Golden,Dorota Szpak,Xiaoxia Z. West,Carla Nestor,Yan-Qing Ma,Katarzyna Bialkowska,Tatiana V. Byzova,Edward F. Plow +10 more
TL;DR: Taken together, kindlin-2 plays an important role in pathologic and developmental angiogenesis, which arises from defective activation of integrin αVβ3.