R
Ralf H. Adams
Researcher at Max Planck Society
Publications - 245
Citations - 29515
Ralf H. Adams is an academic researcher from Max Planck Society. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 81, co-authored 229 publications receiving 24165 citations. Previous affiliations of Ralf H. Adams include London Research Institute & French Institute of Health and Medical Research.
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Journal ArticleDOI
Molecular regulation of angiogenesis and lymphangiogenesis.
Ralf H. Adams,Kari Alitalo +1 more
TL;DR: The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell–cell communication.
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Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
TL;DR: In this paper, the authors identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties, which mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis.
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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Yingdi Wang,Masanori Nakayama,Mara E. Pitulescu,Tim S. Schmidt,Magdalena L. Bochenek,Magdalena L. Bochenek,Akira Sakakibara,Susanne Adams,Susanne Adams,Alice Davy,Urban Deutsch,Urs Lüthi,Alcide Barberis,Laura E. Benjamin,Taija Makinen,Catherine D. Nobes,Ralf H. Adams,Ralf H. Adams +17 more
TL;DR: It is shown with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium, and shows that full VEGFR3 signalling is coupled to receptor internalization.
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Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
Ralf H. Adams,George A. Wilkinson,Cornelia Weiss,Francesca Diella,Nicholas W. Gale,Urban Deutsch,Werner Risau,Rüdiger Klein +7 more
TL;DR: EphrinB ligands induce capillary sprouting in vitro with a similar efficiency as angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF), demonstrating a stimulatory role of ephrins in the remodeling of the developing vascular system.
Journal ArticleDOI
The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis
Rui Benedito,Rui Benedito,Cristina Roca,Inga Sörensen,Susanne Adams,Susanne Adams,Achim Gossler,Marcus Fruttiger,Ralf H. Adams,Ralf H. Adams +9 more
TL;DR: It is shown that the Notch ligand Jagged1 is a potent proangiogenic regulator in mice that antagonizes Dll4-Notch signaling in cells expressing Fringe family glycosyltransferases.