T
Tatiana V. Petrova
Researcher at Ludwig Institute for Cancer Research
Publications - 132
Citations - 14457
Tatiana V. Petrova is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 47, co-authored 110 publications receiving 12322 citations. Previous affiliations of Tatiana V. Petrova include University of Helsinki & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Marika J. Karkkainen,Paula Haiko,Kirsi Sainio,Juha Partanen,Jussi Taipale,Tatiana V. Petrova,Michael Jeltsch,David A. Jackson,Marja Talikka,Heikki Rauvala,Christer Betsholtz,Kari Alitalo +11 more
TL;DR: The results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development.
Journal ArticleDOI
Microenvironmental regulation of tumour angiogenesis
TL;DR: The extrinsic regulation of angiogenesis by the tumour microenvironment is discussed, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies.
Journal ArticleDOI
Lymphangiogenesis in development and human disease
Kari Alitalo,Kari Alitalo,Tuomas Tammela,Tuomas Tammela,Tatiana V. Petrova,Tatiana V. Petrova +5 more
TL;DR: The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood in an important role in the pathogenesis of several diseases, including cancer, lymphoedema and various inflammatory conditions.
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Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice
Tanja Veikkola,Lotta Jussila,Taija Makinen,Terhi Karpanen,Michael Jeltsch,Tatiana V. Petrova,Hajime Kubo,Gavin Thurston,Donald M. McDonald,Marc G. Achen,Steven A. Stacker,Kari Alitalo +11 more
TL;DR: It is demonstrated that stimulation of the VEGFR‐3 signal transduction pathway is sufficient to induce specifically lymphangiogenesis in vivo.
Journal ArticleDOI
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
Tatiana V. Petrova,Taija Makinen,Tomi P. Mäkelä,Janna Saarela,Ismo Virtanen,Robert E. Ferrell,David N. Finegold,Dontscho Kerjaschki,Seppo Ylä-Herttuala,Kari Alitalo +9 more
TL;DR: It is found that isolated human primary lymphatic and blood vascular endothelial cells show interesting differences in gene expression relevant for their distinct functions in vivo, and overexpression of the homeobox transcription factor Prox‐1 in the BECs is suggested to act as a cell proliferation inducer and a fate determination factor for the LECs.