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Xiaoxin Chen
Researcher at North Carolina Central University
Publications - 74
Citations - 3880
Xiaoxin Chen is an academic researcher from North Carolina Central University. The author has contributed to research in topics: Esophagus & Barrett's esophagus. The author has an hindex of 34, co-authored 68 publications receiving 3554 citations. Previous affiliations of Xiaoxin Chen include Capital Medical University & Central University, India.
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Journal ArticleDOI
Modulation of arachidonic acid metabolism by curcumin and related β-diketone derivatives: effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipoxygenase
Jungil Hong,Mousumi Bose,Jihyeung Ju,Jae-Ha Ryu,Xiaoxin Chen,Shengmin Sang,Mao Jung Lee,Chung S. Yang +7 more
TL;DR: Curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX, which may contribute to the anti-inflammatory and anticarcinogenic actions of curcumin and its analogs.
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Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin.
Ning Li,Xiaoxin Chen,Jie Liao,Guang Yu Yang,Su Wang,Youssef Josephson,Chi Han,Junshi Chen,Mou-Tuan Huang,Chung S. Yang +9 more
TL;DR: It is suggested that green tea and curcumin had inhibitory effects against oral carcinogenesis at the post-initiation stage and such inhibition may be related to the suppression of cell proliferation, induction of apoptosis and inhibition of angiogenesis.
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Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention.
Xiaoxin Chen,Chung S. Yang +1 more
TL;DR: It is proposed that the pathogenesis of EAC is mainly driven by inflammation and oxidative stress, which are augmented by iron overload, and antioxidants, inhibitors of arachidonic acid metabolism enzymes and receptor antagonists of certain eicosanoids are proposed as potential chemopreventive agents for EAC in future studies.
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Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells
Tong Liu,Xinyan Zhang,Xinyan Zhang,Chi-Kwong So,Su Wang,Peng Wang,Liying Yan,Rene Myers,Zhigang Chen,Amy P. Patterson,Chung S. Yang,Xiaoxin Chen,Xiaoxin Chen +12 more
TL;DR: It is suggested that exposure to acid and/or bile acids may activate Cdx2 expression in human esophageal epithelial cells through promoter demethylation, and ectopic Cdx 2 expression in esophagal squamous epithel cells may contribute to intestinal metaplasia of the esophagus.
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Oxidative damage in an esophageal adenocarcinoma model with rats
TL;DR: It is proposed that oxidative damage plays an important role in the formation of EAC in the EDA model, and a similar situation may occur in humans with gastroesophageal reflux and iron over-nutrition.