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Xiaoxin Chen
Researcher at North Carolina Central University
Publications - 74
Citations - 3880
Xiaoxin Chen is an academic researcher from North Carolina Central University. The author has contributed to research in topics: Esophagus & Barrett's esophagus. The author has an hindex of 34, co-authored 68 publications receiving 3554 citations. Previous affiliations of Xiaoxin Chen include Capital Medical University & Central University, India.
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Journal ArticleDOI
Quantitative Risk Stratification of Oral Leukoplakia with Exfoliative Cytology
Yao Liu,Jianying Li,Xiaoyong Liu,Xudong Liu,Waqaar Khawar,Xinyan Zhang,Fan Wang,Xiaoxin Chen,Zheng Sun +8 more
TL;DR: This method may potentially improve cost-effectiveness of clinical follow-up of OLK patients, and help design clinical chemoprevention trial for high-risk populations.
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Single Nucleotide Polymorphisms of Caudal Type Homeobox 1 and 2 Are Associated with Barrett’s Esophagus
Dongren Ren,Dongren Ren,Gaolin Zheng,Susan Bream,Whitney Tevebaugh,Nicholas J. Shaheen,Xiaoxin Chen,Xiaoxin Chen +7 more
TL;DR: Certain SNPs of Cdx1 and Cdx2 and their interactions with other risk factors are associated with BE, and may contribute to human susceptibility to BE.
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Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium.
TL;DR: Transgenic overexpression of cdx1b failed to induce histological IM, or to modulate cell proliferation and apoptosis in the squamous epithelium of adult transgenic zebrafish.
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NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma.
Joab Otieno Odera,Zhaohui Xiong,Caizhi Huang,Ning Gu,Wenjun Yang,Jessie Githanga,Elizabeth Odera,Chorlada Paiboonrungruang,Xiaoxin Chen,Xiaoxin Chen +9 more
TL;DR: The NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on ESCC, and was found to upregulate acetyl-CoA synthetase short-chain family members 2 (AC SS2), an enzyme that converts acetate to acetate, in ESCC cells and mouse esophagus.
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Zebrafish K5 promoter driven GFP expression as a transgenic system for oral research
TL;DR: A high fidelity of GFP reporter gene expression in the tongue under the control of zebrafish keratin 5 promoter is indicated, which may be used for future studies on oral development and cancer.