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Xiaoxin Chen
Researcher at North Carolina Central University
Publications - 74
Citations - 3880
Xiaoxin Chen is an academic researcher from North Carolina Central University. The author has contributed to research in topics: Esophagus & Barrett's esophagus. The author has an hindex of 34, co-authored 68 publications receiving 3554 citations. Previous affiliations of Xiaoxin Chen include Capital Medical University & Central University, India.
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Journal ArticleDOI
Leukotriene A4 Hydrolase in Rat and Human Esophageal Adenocarcinomas and Inhibitory Effects of Bestatin
Xiaoxin Chen,Ning Li,Su Wang,Nan Wu,Jungil Hong,Xiaolong Jiao,Mark J. Krasna,David G. Beer,Chung S. Yang +8 more
TL;DR: LTA4H overexpression appears to be an early event in esophageal adenocarcinogenesis and is a potential target for the chemoprevention of EAC.
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Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans
TL;DR: The data suggest a possible correlation between oxidative stress, Grp94 overexpression and apoptosis regulation in esophageal adenocarcinogenesis.
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Studies of iron deposits, inducible nitric oxide synthase and nitrotyrosine in a rat model for esophageal adenocarcinoma.
TL;DR: Iron supplementation enhanced inflammation and the production of reactive oxygen and nitrogen species in the esophageal epithelium and these processes could contribute to the formation of Barrett's esophagus and its progression to EAC.
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Identification of arsenic-binding proteins in human breast cancer cells
TL;DR: Binding assay with Western blotting confirmed binding of beta-tubulin and PKM2 by arsenic in a concentration-dependent manner and functional consequence of such binding may depend on whether arsenic binding causes conformational changes or blocks active sites of target proteins.
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Diagnostic Utility of Major Basic Protein, Eotaxin-3, and Leukotriene Enzyme Staining in Eosinophilic Esophagitis
TL;DR: Patients with EoE had substantially higher levels of MBP and eotaxin-3 staining than GERD patients, suggesting these markers may have utility as a diagnostic assay for Eo E.