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Xicheng Wang
Researcher at Dalian University of Technology
Publications - 25
Citations - 779
Xicheng Wang is an academic researcher from Dalian University of Technology. The author has contributed to research in topics: Virtual screening & Docking (molecular). The author has an hindex of 16, co-authored 25 publications receiving 726 citations. Previous affiliations of Xicheng Wang include East China University of Science and Technology.
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PDTD: a web-accessible protein database for drug target identification
Zhenting Gao,Zhenting Gao,Honglin Li,Honglin Li,Hailei Zhang,Xiaofeng Liu,Ling Kang,Xiaomin Luo,Weiliang Zhu,Kaixian Chen,Xicheng Wang,Hualiang Jiang,Hualiang Jiang +12 more
TL;DR: PDTD serves as a comprehensive and unique repository of drug targets and in conjunction with TarFisDock, PDTD can be used to identify binding proteins for small molecules and may be a valuable platform for the pharmaceutical researchers.
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Mechanics of channel gating of the nicotinic acetylcholine receptor.
Xinli Liu,Yechun Xu,Honglin Li,Xicheng Wang,Hualiang Jiang,Hualiang Jiang,Francisco J. Barrantes +6 more
TL;DR: The present MD simulations explore the structural dynamics of the receptor under its gating process and provide a new insight into the gating mechanism of nAChR at the atomic level.
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GAsDock: a new approach for rapid flexible docking based on an improved multi-population genetic algorithm
Honglin Li,Chunlian Li,Chunshan Gui,Xiaomin Luo,Kaixian Chen,Jianhua Shen,Xicheng Wang,Hualiang Jiang +7 more
TL;DR: GAsDock is an accurate and remarkably faster docking program in comparison with other docking programs, which is applausive in the application of virtual screening.
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Cyndi: a multi-objective evolution algorithm based method for bioactive molecular conformational generation
Xiaofeng Liu,Fang Bai,Sisheng Ouyang,Xicheng Wang,Honglin Li,Honglin Li,Honglin Li,Hualiang Jiang,Hualiang Jiang +8 more
TL;DR: The results reveal that Cyndi is capable of generating geometrically diverse conformers and outperforms other four multiple conformer generators in the case of reproducing the bioactive conformations against 329 structures and is a powerful alternative method for extensive conformational sampling and large-scale conformer database preparation.
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An improved PMF scoring function for universally predicting the interactions of a ligand with protein, DNA, and RNA.
Xiaoyu Zhao,Xiaofeng Liu,Yuanyuan Wang,Zhi Chen,Ling Kang,Hailei Zhang,Xiaomin Luo,Weiliang Zhu,Kaixian Chen,Honglin Li,Xicheng Wang,Hualiang Jiang +11 more
TL;DR: An improved potential mean force scoring function, named KScore, has been developed by using 23 redefined ligand atom types and 17 protein atom types, as well as 28 newly introduced atom types for nucleic acids (DNA and RNA).