Xigeng Zhao

TL;DR: It is found that neutrophils were rapidly recruited to the lungs following i.n. inoculation of the pathogen and declined to baseline level upon clearance of the infection, implying that neutophils play a critical role in host resistance to respiratory A. baumannii infection.

TL;DR: In this model, interferon gamma (IFNgamma) and CD4+ and CD8+ T cells are essential for the expression of anti-Francisella immunity in the lungs, and this immune response operates by limiting dissemination of the pathogen to susceptible internal organs.

TL;DR: Sera and infected tissues from C57BL/6 and BALB/c mice challenged by natural intradermal and respiratory routes with one of two distinct type A strains of the pathogen are examined for cytokine and chemokine responses that might help to explain the morbidity associated with tularemia.

TL;DR: In this article, the authors examined the susceptibility of mice to intragastric inoculation with virulent type A F. tularensis and characterized the course of infection and the associated host responses.

TL;DR: An immunoproteomics approach was used to survey the repertoire of antibodies in sera from individuals who had contracted tularemia during two outbreaks and individuals from two geographical areas who had been vaccinated with NDBR Lot 11 or Lot 17 LVS, showing a large overlap in the antibodies generated in response to Tularemia infection or LVS vaccination.