Xinwen Wang

TL;DR: Type 2 innate lymphoid cells promote skin inflammation in mice and men, in part by producing IL-5 and IL-13 in response to IL-33.

TL;DR: Atopic dermatitis is a common inflammatory skin disorder, characterized by skin barrier defects and enhanced allergen priming, and Null mutations in the filaggrin gene (FLG) are strongly associated with moderate to severe AD.

TL;DR: The importance of filaggrin, a late differentiation protein expressed by keratinocytes, has been recently highlighted and supported by findings from cohort studies around the world, which imply an important role of skin barrier insufficiency in the subsequent activation of allergen-specific T cells.

TL;DR: The results suggest that, in combination with atopic dermatitis milieu, C. albicans promotes alterations in the glycosylation pattern of keratinocyte-derived sEVs to interact with inhibitory Siglecs on antigen presenting cells could offer novel therapeutic options for skin candidiasis in AD.

TL;DR: This review aims to provide an update on the most recent progress in the identification and characterization of bacteria in GI diseases in a variety of organ systems and clinical conditions, and examine the invasion and escape mechanisms of pathogens that have been demonstrated in previous studies.