D
David Johnson
Researcher at John Radcliffe Hospital
Publications - 59
Citations - 3141
David Johnson is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Craniosynostosis & Craniofacial. The author has an hindex of 26, co-authored 54 publications receiving 2708 citations. Previous affiliations of David Johnson include University of Bristol & University of Oxford.
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Journal ArticleDOI
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
Maryam Salimi,Jillian L. Barlow,Sean P. Saunders,Luzheng Xue,Danuta Gutowska-Owsiak,Xinwen Wang,Li-Chieh Huang,David Johnson,Seth T. Scanlon,Andrew N. J. McKenzie,Padraic G. Fallon,Padraic G. Fallon,Graham S. Ogg +12 more
TL;DR: Type 2 innate lymphoid cells promote skin inflammation in mice and men, in part by producing IL-5 and IL-13 in response to IL-33.
Journal ArticleDOI
Genomic Screening of Fibroblast Growth-Factor Receptor 2 Reveals a Wide Spectrum of Mutations in Patients with Syndromic Craniosynostosis
Shih-hsin Kan,N Elanko,David Johnson,Laura R. Cornejo-Roldan,Jackie Cook,Elsa Reich,Susan Tomkins,Alain Verloes,Stephen R.F. Twigg,Sahan V. Rannan-Eliya,Donna M. McDonald-McGinn,Elaine H. Zackai,Steven A. Wall,Maximilian Muenke,Andrew O.M. Wilkie +14 more
TL;DR: The spectrum of FGFR2 mutations causing craniosynostosis is wider than previously recognized but that, nevertheless, the IgIIIa/IIIc region represents a genuine mutation hotspot.
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De novo alu-element insertions in FGFR2 identify a distinct pathological basis for Apert syndrome.
Michael Oldridge,Elaine H. Zackai,Donna M. McDonald-McGinn,Sachiko Iseki,Gillian M. Morriss-Kay,Stephen R.F. Twigg,David Johnson,Steven A. Wall,Wen Jiang,Christiane Theda,Ethylin Wang Jabs,Andrew O.M. Wilkie +11 more
TL;DR: Ectopic expression of KGFR in the fibroblast lines correlated with the severity of limb abnormalities provides the first genetic evidence that signaling through KG FR causes syndactyly in Apert syndrome.
Journal ArticleDOI
Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.
Andrew O.M. Wilkie,Jo C. Byren,Jane A. Hurst,Jayaratnam Jayamohan,David Johnson,Samantha J. L. Knight,Samantha J. L. Knight,Tracy Lester,Peter G. Richards,Stephen R.F. Twigg,Steven A. Wall +10 more
TL;DR: The first cohort-based analysis of the impact of genetic disorders in craniosynostosis is described and genetic testing of nonsyndromic cases should be targeted to patients with coronal or multisuture synostoses.
Journal ArticleDOI
A Comprehensive Screen for TWIST Mutations in Patients with Craniosynostosis Identifies a New Microdeletion Syndrome of Chromosome Band 7p21.1
David Johnson,Sharon W. Horsley,Dominique M. Moloney,Michael Oldridge,Stephen R.F. Twigg,Sinead Walsh,Margaret Barrow,Pål R. Njølstad,Jürgen Kunz,Geraldine J. Ashworth,Steven A. Wall,Lyndal Kearney,Andrew O.M. Wilkie +12 more
TL;DR: The results identify a new microdeletion disorder that maps to chromosome band 7p21.1 and that causes a significant proportion of Saethre-Chotzen syndrome.