Xiuyuan Ou

TL;DR: It is shown that the SARS-CoV-2 spike protein is less stable than that of SARS -CoV, and limited cross-neutralization activities between SARS and COVID-19 patients’ sera showlimited cross- neutralization activities, suggesting that recovery from one infection might not protect against the other.

TL;DR: The location and amino acid sequences of the FPs of S glycoproteins of 3 β-CoVs, MERS- coV, SARS-CoV, and MHV were determined and it was demonstrated that they were essential for mediating cell-cell fusion and virus entry.

TL;DR: Five residues in the insertion subdomain that are critical for binding of neutralizing antibodies and two residues essential for receptor binding are identified, contributing to a better understanding of entry, immunity and evolution of CoV S proteins.

TL;DR: It is shown that the purified C domain, downstream of the NTD, could block HKU1 virus infection of human respiratory epithelial cells, and that several monoclonal antibodies that mapped to the C domain neutralized virus infectivity.