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Xizhen Lian
Researcher at Texas A&M University
Publications - 16
Citations - 2454
Xizhen Lian is an academic researcher from Texas A&M University. The author has contributed to research in topics: Nanoreactor & Coordination cage. The author has an hindex of 13, co-authored 14 publications receiving 1772 citations. Previous affiliations of Xizhen Lian include Texas A&M University System.
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Journal ArticleDOI
Enzyme–MOF (metal–organic framework) composites
Xizhen Lian,Yu Fang,Elizabeth A. Joseph,Qi Wang,Jialuo Li,Sayan Banerjee,Christina T. Lollar,Xuan Wang,Hong-Cai Zhou +8 more
TL;DR: This review summarizes recent developments of MOF-enzyme composites with special emphasis on preparative techniques and the synergistic effects of enzymes and MOFs.
Journal ArticleDOI
Stable metal-organic frameworks containing single-molecule traps for enzyme encapsulation
Dawei Feng,Tian-Fu Liu,Jie Su,Mathieu Bosch,Zhangwen Wei,Wei Wan,Daqiang Yuan,Ying-Pin Chen,Xuan Wang,Kecheng Wang,Xizhen Lian,Zhi-Yuan Gu,Jihye Park,Xiaodong Zou,Hong-Cai Zhou +14 more
TL;DR: With extraordinarily large pore size and excellent chemical stability, PCN-333 may be of interest not only for enzyme encapsulation, but also for entrapment of other nanoscaled functional moieties.
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Enzyme‐MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy
Xizhen Lian,Yanyan Huang,Yuanyuan Zhu,Yu Fang,Rui Zhao,Elizabeth A. Joseph,Jialuo Li,Jean-Philippe Pellois,Hong-Cai Zhou +8 more
TL;DR: Tyrosinase-MOF nanoreactors cause significant cell death in the presence of paracetamol for up to three days after being internalized by cells, while free enzymes totally lose activity in a few hours.
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Coupling two enzymes into a tandem nanoreactor utilizing a hierarchically structured MOF
TL;DR: A hierarchically structured MOF is utilized to couple two enzymes in a tandem manner and a stepwise encapsulation with a specific order is the only way to achieve this goal.
Journal ArticleDOI
Cooperative Cluster Metalation and Ligand Migration in Zirconium Metal–Organic Frameworks
Shuai Yuan,Ying-Pin Chen,Jun-Sheng Qin,Weigang Lu,Xuan Wang,Qiang Zhang,Mathieu Bosch,Tian-Fu Liu,Xizhen Lian,Hong-Cai Zhou +9 more
TL;DR: This work provides a powerful tool to functionalize Zr-MOFs with other metals, but also structurally elucidates the formation mechanism of the resulting heterometallic MOFs.