X
Xu Zhang
Researcher at Chinese Academy of Sciences
Publications - 245
Citations - 10698
Xu Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Dorsal root ganglion & Medicine. The author has an hindex of 57, co-authored 201 publications receiving 9639 citations. Previous affiliations of Xu Zhang include ShanghaiTech University & Fourth Military Medical University.
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Journal ArticleDOI
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
TL;DR: Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed, thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.
Journal ArticleDOI
Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
Hua-Sheng Xiao,Qiu-Hua Huang,FX Zhang,Lan Bao,YJ Lu,C Guo,Liang Yang,WJ Huang,Gang Fu,Shuhua Xu,XP Cheng,Qing Yan,Zhi-Dong Zhu,Xu Zhang,Zi-Jiang Chen,Ze-Guang Han +15 more
TL;DR: CDNA array on genes mainly made from the cDNA libraries of lumbar DRGs of normal rats and of rats 14 days after peripheral axotomy reveals dynamic and complex changes in molecular diversity among DRG neurons after axotomy.
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Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity.
Chang-Lin Li,Kai-Cheng Li,D. J. Wu,Yan Chen,Hao Luo,Jingrong Zhao,Sashuang Wang,Ming-Ming Sun,Ying-Jin Lu,Yan-Qing Zhong,Xu-Ye Hu,Rui Hou,Bei-Bei Zhou,Lan Bao,Hua-Sheng Xiao,Xu Zhang +15 more
TL;DR: This work classifies somatosensory neurons of the mouse dorsal root ganglion (DRG) by high-coverage single-cell RNA-sequencing and neuron size-based hierarchical clustering and provides a new system for cataloging somatosENSory neurons and their transcriptome databases.
Journal ArticleDOI
Nitric oxide synthase in the rat anterior pituitary gland and the role of nitric oxide in regulation of luteinizing hormone secretion.
Sandra Ceccatelli,Anna-Lena Hulting,Xu Zhang,Lars Gustafsson,Marcelo J. Villar,Tomas Hökfelt +5 more
TL;DR: Findings support a dual mechanism for NO in the control of anterior pituitary hormone secretion, an autocrine mediation of luteinizing hormone release on gonadotrophs, and a paracrine effect on growth hormone secretion involving folliculo-stellate cells closely related to somatotrophic cells.
Journal ArticleDOI
Nitric oxide synthase-like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy
Xu Zhang,Valerie M. K. Verge,Zsuzsanna Wiesenfeld-Hallin,Gong Ju,David S. Bredt,Solomon H. Snyder,Tomas Hökfelt +6 more
TL;DR: It is demonstrated that axotomy in rat induces a marked upregulation of NOS synthesis in primary sensory neurons, thus suggesting a role for NO in lesioned sensory neurons.