Z
Ze-Guang Han
Researcher at Shanghai Jiao Tong University
Publications - 191
Citations - 10954
Ze-Guang Han is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Gene & Carcinogenesis. The author has an hindex of 45, co-authored 184 publications receiving 9319 citations. Previous affiliations of Ze-Guang Han include East China University of Science and Technology & Chinese National Human Genome Center.
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Journal ArticleDOI
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.
TL;DR: This study constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection, and identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileal cells, and bladder urothelial cells).
Journal ArticleDOI
The Schistosoma japonicum genome reveals features of host-parasite interplay
Yan Zhou,Huajun Zheng,Yangyi Chen,Lei Zhang,Kai Wang,Jing Guo,Zhen Huang,Bo Zhang,Wei Huang,Ke Jin,Tonghai Dou,Masami Hasegawa,Li Wang,Yuan Zhang,Jie Zhou,Lin Tao,Zhiwei Cao,Yixue Li,Tomas Vinar,Brona Brejová,Daniel G. Brown,Ming Li,David J. Miller,David Blair,Yang Zhong,Zhu Chen,Feng Liu,Wei Hu,Zhi-Qin Wang,Qin-Hua Zhang,Huai-Dong Song,Sai-Juan Chen,Xue-Nian Xu,Bin Xu,Chuan Ju,Yucheng Huang,Paul J. Brindley,Donald P. McManus,Zheng Feng,Ze-Guang Han,Gang Lu,Shuang-Xi Ren,Y.S. Wang,Wenyi Gu,Hui Kang,Jie Chen,Xiaoyun Chen,Shuting Chen,Lijun Wang,Jie Yan,Biyun Wang,Xinyan Lv,Lei Jin,Bofei Wang,Shiyin Pu,Xiang-Lin Zhang,Wei Zhang,Qiuping Hu,Genfeng Zhu,Jun Wang,Jun Yu,Jing Wang,Huanming Yang,Zemin Ning,Matthew Beriman,Chia-Lin Wei,Yijun Ruan,Guoping Zhao,Shengyue Wang +68 more
TL;DR: The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation.
Journal ArticleDOI
Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
Hua-Sheng Xiao,Qiu-Hua Huang,FX Zhang,Lan Bao,YJ Lu,C Guo,Liang Yang,WJ Huang,Gang Fu,Shuhua Xu,XP Cheng,Qing Yan,Zhi-Dong Zhu,Xu Zhang,Zi-Jiang Chen,Ze-Guang Han +15 more
TL;DR: CDNA array on genes mainly made from the cDNA libraries of lumbar DRGs of normal rats and of rats 14 days after peripheral axotomy reveals dynamic and complex changes in molecular diversity among DRG neurons after axotomy.
Journal ArticleDOI
Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.
Xiangru Xu,Jian Huang,Zhigang Xu,Bin-Zhi Qian,Zhi-Dong Zhu,Qing Yan,Ting Cai,Xin Zhang,Hua-Sheng Xiao,Jian Qu,Feng Liu,Qiu-Hua Huang,Zhihong Cheng,Li Nenggan,Jianjun Du,Wei Hu,Kuntang Shen,Gang Lu,Gang Fu,Ming Zhong,Shuhua Xu,Wenyi Gu,Wei Huang,Xin-Tai Zhao,Geng-Xi Hu,Jian-Ren Gu,Zhu Chen,Ze-Guang Han +27 more
TL;DR: In this paper, a comprehensive characterization of gene expression profiles of hepatitis B virus-positive HCC through the generation of a large set of 5′-read expressed sequence tag (EST) clusters (11,065 in total) from HCC and non-cancerous liver samples, which then were applied to a cDNA microarray system containing 12,393 genes/ESTs and to comparison with a public database.
Journal ArticleDOI
Exome sequencing of hepatitis B virus–associated hepatocellular carcinoma
Jian Huang,Qing Deng,Qing Deng,Qun Wang,Qun Wang,Kun Yu Li,Ji Hong Dai,Niu Li,Niu Li,Zhi Dong Zhu,Bo Zhou,Bo Zhou,Xiao Yan Liu,Xiao Yan Liu,Ruifang Liu,Qian Lan Fei,Hui Chen,Bing Cai,Boping Zhou,Hua Sheng Xiao,Lun Xiu Qin,Ze-Guang Han,Ze-Guang Han +22 more
TL;DR: Exome sequencing is used to identify somatic mutations in HBV-positive individuals with HCC with portal vein tumor thromboses (PVTTs), intrahepatic metastases and suggests that seven genes, including VCAM1 and CDK14, may confer growth and infiltration capacity to HCC cells.