다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

■ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death that can be triggered by a variety of physiological and pathological stimuli. Studies performed over the past 10 years have demonstrated that proteases play critical roles in initiation and execution of this process. The caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases. Caspases are synthesized as relatively inactive zymogens that become activated by scaffold-mediated transactivation or by cleavage via upstream proteases in an intracellular cascade. Regulation of caspase activation and activity occurs at several different levels: ( a) Zymogen gene transcription is regulated; ( b) antiapoptotic members of the Bcl-2 family and other cellular polypeptides block proximity-induced activation of certain procaspases; and ( c) certain cellular inhibitor of apoptosis proteins (cIAPs) can bind to and inhibit active caspases. Once activated, caspases cleave a variety of intracellular polypeptides, including major structural elements of the cytoplasm and nucleus, components of the DNA repair machinery, and a number of protein kinases. Collectively, these scissions disrupt survival pathways and disassemble important architectural components of the cell, contributing to the stereotypic morphological and biochemical changes that characterize apoptotic cell death.

Mammalian caspases: structure ,a ctivation ,s ubstrates, and functions during apoptosis

https://bioone.org/journals/harvard-papers-in-botany/volume-13/issue-2/1043-4534-13.2.299/Flora-of-China/10.3100/1043-4534-13.2.299.pdf

Flora of China

Current approaches and challenges for the metabolite profiling of complex natural extracts

Natural carrier-free self-assembled diterpene nanoparticles with its efficient anti-inflammation through the inhibition of NF-κB pathway for accelerated wound healing.

Abstract In the phylogenetic tree of RRM-type Rbps (RNA-binding proteins) in cyanobacteria, Rbp1 of Synechocystis 6803, with a single RRM (RNA recognition motif) region and a C-terminal glycine-rich region, and Rbp2, without the C-terminal region, both belong to the cluster I, whereas Rbp3 with a different type of C-terminal region is in the cluster II. Rbp1 is required for the cold adaptability of the cyanobacterium, and Rbp3 is for salt tolerance. Here, we report that the C-terminal region of Rbp1 is not required for the cold adaptability function but the C-terminal region of Rbp3 can direct the RRM of Rbp1 to the salt tolerance function. Bioinformatic and experimental analyses indicate that Rbps in cyanobacteria should be classified as two types. It is the first report for the distinct roles of C-terminal regions of Rbps in stress tolerance of cyanobacteria.

Two types of C-terminal regions of RNA-binding proteins play distinct roles in stress tolerance of Synechocystis sp. PCC 6803

isolation, structure elucidation and inhibitory activity against LPS-induced NO production in macrophages

Two New Triterpenoid Glycosides from the Roots of Rosa cymosa Tratt

Efficient electrochemical semi-hydrogenation (ECSH) of alkynes to alkenes is a promising alternative to traditional thermal semi-hydrogenation. Mechanistic understanding of crystal plane-dependent ECSH performance is extremely important for the subsequent catalyst design. Here, we investigate the role of low-index Pd(hkl) surfaces, including Pd (100), (111), and (110) planes, in ECSH of alkynes. As a result, alkyne conversion rate and alkene selectivity of Pd(hkl) surfaces follow the order of Pd (100) > Pd (111) > Pd (110). In situ Raman spectroscopic evidence indicates that the Pd (100) plane effectively enhances the formation of K+ ion hydrated water and two-coordinated hydrogen-bonded water to accelerate semi-hydrogenation rate and improve alkene selectivity, respectively. The order of the ability to regulate the interfacial water structure is ideally consistent with that of ECSH performance on Pd(hkl) surfaces. Pd nanocubes enclosed by the (100) surface exhibit excellent ECSH activity, alkene selectivity, and cycling stability. These findings demonstrate that the interfacial water structure is crystal plane-dependent, which is the determining factor for ECSH. 

Effect of Crystal Planes of Pd and the Structure of Interfacial Water on the Electrocatalytic Hydrogenation of Alkynes to Alkenes

Terpenes possess a wide range of structural features and pharmaceutical activities and are promising for drug candidates. With the aim to find bioactive terpene molecules, eight new compounds were isolated from the medicinal plant Nepeta bracteata Benth., including seven new abietane-type diterpenoids (1–7), along with a new ursane-type triterpenoid (8). The structures of compounds 1–8 were elucidated through the detailed spectroscopic analyses of their 1D and 2D NMR and MS data, and the absolute configurations of compounds 1–7 were determined by comparing their experimental and calculated ECD spectra. Compound 1 was a novel degraded carbon diterpene with the disappearing of methyl signal at C-19, while compound 7 possessed a new norabietane-type diterpenoid carbon skeleton with the presence of five-membered lactone arising from ring rearrangement. The anti-inflammatory of all obtained isolates were evaluated on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the results of anti-inflammatory activity screening showed that compared with the LPS model group, all compounds were significantly down-regulation the TNF-α inflammatory factor at the specific concentration, except for compound 6.

/pdf/abietane-type-diterpenoids-from-nepeta-bracteata-benth-and-3v3yy8lv.pdf

Xudong Xu

Papers

Natural carrier-free self-assembled diterpene nanoparticles with its efficient anti-inflammation through the inhibition of NF-κB pathway for accelerated wound healing.

Two types of C-terminal regions of RNA-binding proteins play distinct roles in stress tolerance of Synechocystis sp. PCC 6803

Two New Triterpenoid Glycosides from the Roots of Rosa cymosa Tratt

Effect of Crystal Planes of Pd and the Structure of Interfacial Water on the Electrocatalytic Hydrogenation of Alkynes to Alkenes

Abietane-Type Diterpenoids From Nepeta bracteata Benth. and Their Anti-Inflammatory Activity