Xueli Zhang

TL;DR: An aptamer-trigger-clamped hybridization chain reaction (atcHCR) method for the capture of CTCs by porous 3D DNA hydrogels that can be used to quantitively identify as few as 10 MCF-7 cells in a 2-µL blood sample.

TL;DR: It is found that TO-DNA maintains the transcription activity whereas the activity is critically dependent on the configuration of the T7 promoter in a folded DNA nanostructure, and the design of TO-DNAs provides a means for shape-dependent gene delivery, enriching the toolbox of genetic engineering and synthetic biology.

TL;DR: This review systematically compared the benefits of RE nanoparticles with other NIR probes, and summarized the recent advances of NIR emissiveRE nanoparticles in bioimaging, photodynamic therapy, drug delivery and NIR fluorescent IGS.

TL;DR: A review of the recent advances in the development of ROPs including molecular design principles, activated mechanisms and treatment responses for photoacoustic and NIR-II fluorescence imaging is reviewed in this paper.

TL;DR: A toehold switch-based approach to engineer the conformation of single guide RNA (sgRNA) for programmable activation of Cas9 with orthogonal DNA inputs is reported, which provides a new route to program CRISPR in living cells for genome imaging and engineering.