Y
Y. Shu
Researcher at Nanjing Medical University
Publications - 24
Citations - 916
Y. Shu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 7, co-authored 13 publications receiving 655 citations.
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Journal ArticleDOI
SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer
TL;DR: It is reported that TINCR is strongly upregulated in human gastric carcinoma (GC), where it was found to contribute to oncogenesis and cancer progression, and may constitute a potential therapeutic target in this disease.
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Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2
TL;DR: This is the first report which showed the role of PANDAR in the progression of NSCLC, and it was shown that PANDar-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affectingNSCLC cell apoptosis.
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Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells
Wan Li,Ming Sun,Chongshuang Zang,Pei Ma,Jun He,Mingjiong Zhang,Zheng-Ru Huang,Yuzhi Ding,Y. Shu +8 more
TL;DR: Analysis of lncRNA expression in human NSCLC samples by using microarray data from Gene Expression Omnibus indicates that AGAP2-AS1 may act as an oncogene by repressing tumor-suppressor LATS2 and KLF2 transcription.
Journal ArticleDOI
Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling.
Zhumei Shi,Linjun Wang,Hongbing Shen,Jiang Cf,Xin Ge,Li Dm,Wen Yy,Huiling Sun,Pan Mh,Li W,Y. Shu,Ling-Zhi Liu,Stephen C. Peiper,Jun He,Bing-Hua Jiang,Bing-Hua Jiang +15 more
TL;DR: An important role is highlighted in the regulation of EMT-related traits and metastasis of lung cancer in part by modulation of Slug/ZEB2 signaling, and a potential therapeutic strategy by targeting miR-218 in NSCLC is provided.
Journal ArticleDOI
Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression
Q. Xu,Ling-Zhi Liu,Yin Yin,Yin Yin,Jun He,Qingya Li,Xu Qian,Yongping You,Zhimin Lu,Stephen C. Peiper,Y. Shu,Bing-Hua Jiang,Bing-Hua Jiang +12 more
TL;DR: It is shown that disruption of PKM2/NF-κB/miR-148a/152 feedback loop can regulate cancer cell growth and angiogenesis, and is also associated with triple-negative breast cancer (TNBC) phenotype, which may have clinical implication for providing novel biomarkers of TNBC and potential therapeutic target(s) in the future.