X
Xu Qian
Researcher at Nanjing Medical University
Publications - 58
Citations - 3707
Xu Qian is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Medicine & Phosphorylation. The author has an hindex of 30, co-authored 42 publications receiving 2623 citations. Previous affiliations of Xu Qian include University of Texas MD Anderson Cancer Center & Yahoo!.
Papers
More filters
Journal ArticleDOI
MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis
Qing Feng Xu,Ling-Zhi Liu,Xu Qian,Qi Chen,Yue Jiang,Dan Li,Lihui Lai,Bing-Hua Jiang,Bing-Hua Jiang +8 more
TL;DR: These studies suggest that miR-145 serves as a tumor suppressor which downregulates HIF-1 and VEGF expression by targeting p70S6K1, leading to the inhibition of tumor growth and angiogenesis.
Journal ArticleDOI
KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase.
Yugang Wang,Yusong R. Guo,Ke Liu,Zheng Yin,Rui Liu,Yan Xia,Lin Tan,Peiying Yang,Jong Ho Lee,Xinjian Li,David H. Hawke,Yanhua Zheng,Xu Qian,Jianxin Lyu,Jie He,Dongming Xing,Yizhi Jane Tao,Zhimin Lu +17 more
TL;DR: The findings reveal an important mechanism of histone modification and demonstrate that local generation of succinyl-CoA by the nuclear α-KGDH complex coupled with the succinyltransferase activity of KAT2A is instrumental in histone succinylation, tumour cell proliferation, and tumour development.
Journal ArticleDOI
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy
Xinjian Li,Willie Yu,Xu Qian,Yan Xia,Yanhua Zheng,Jong Ho Lee,Wei Li,Jianxin Lyu,Ganesh Rao,Xiaochun Zhang,Chao Nan Qian,Steven G. Rozen,Tao Jiang,Zhimin Lu +13 more
TL;DR: It is demonstrated that glucose deprivation results in AMP-activated protein kinase (AMPK)-mediated acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659, which exposed the nuclear localization signal of ACSS2 for importin α5 binding and nuclear translocation.
Journal ArticleDOI
Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
Xu Qian,Xinjian Li,Qingsong Cai,Chuanbao Zhang,Qiujing Yu,Yuhui Jiang,Jong Ho Lee,David H. Hawke,Yugang Wang,Yan Xia,Yan Xia,Yanhua Zheng,Yanhua Zheng,Bing-Hua Jiang,David Liu,Tao Jiang,Zhimin Lu,Zhimin Lu +17 more
TL;DR: This study unearths an important mechanism underlying cellular-stress-induced autophagy initiation in which the protein kinase activity of the metabolic enzyme PGK1 plays an instrumental role and reveals the significance of the mutual regulation ofautophagy and cell metabolism in maintaining cell homeostasis.
Journal ArticleDOI
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
Jong Ho Lee,Rui Liu,Rui Liu,Jing Li,Jing Li,Chuanbao Zhang,Yugang Wang,Qingsong Cai,Xu Qian,Yan Xia,Yanhua Zheng,Yuji Piao,Qianming Chen,John de Groot,Tao Jiang,Zhimin Lu,Zhimin Lu +16 more
TL;DR: It is shown that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on residue S386.