scispace - formally typeset
Y

Yair Dorsett

Researcher at University of Connecticut Health Center

Publications -  25
Citations -  9726

Yair Dorsett is an academic researcher from University of Connecticut Health Center. The author has contributed to research in topics: Chromosomal translocation & Gene. The author has an hindex of 16, co-authored 21 publications receiving 9173 citations. Previous affiliations of Yair Dorsett include Washington University in St. Louis & Rockefeller University.

Papers
More filters
Journal ArticleDOI

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

Daniel Hawiger, +10 more
- 17 Sep 2001 - 
TL;DR: An antigen delivery system targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
Journal ArticleDOI

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

Gunter Meister, +5 more
- 23 Jul 2004 - 
TL;DR: In this paper, it was shown that miRNAs are incorporated indiscriminately of their sequence into Ago1 through Ago4 containing microRNPs (miRNPs) and endonuclease activity is exclusively associated with Ago2.
Journal Article

Human argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

Gunter Meister, +5 more
- 01 Jan 2007 - 
TL;DR: The authors' results suggest that miRNAs are incorporated indiscriminately of their sequence into Ago1 through Ago4 containing microRNPs (miRNPs), and the specific role of Ago2 in guiding target RNA cleavage was confirmed by siRNA-based depletion of individual Ago members in combination with a sensitive positive-readout reporter assay.
Journal ArticleDOI

siRNAs: applications in functional genomics and potential as therapeutics.

Yair Dorsett, +1 more
- 01 Apr 2004 - 
TL;DR: Current nucleic-acid-based approaches for gene silencing are overviews, and the application of siRNAs in particular in functional genomics and as potential therapeutics is focused on.
Journal Article

siRNAs : Applications in functional genomics and potential as therapeutics

Yair Dorsett, +1 more
- 01 Jan 2005 - 
TL;DR: The use of small interfering RNA (siRNA) is one of the latest additions to the repertoire of sequence-specific gene-silencing agents as mentioned in this paper, and the robustness of this approach has motivated numerous biotechnology organizations and academic institutions to develop siRNA libraries for high-throughput genomewide screening in mammalian cells.