G
Guocan Wang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 49
Citations - 5481
Guocan Wang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Prostate cancer & PTEN. The author has an hindex of 23, co-authored 43 publications receiving 3936 citations. Previous affiliations of Guocan Wang include Memorial Sloan Kettering Cancer Center & Nagoya Institute of Technology.
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Journal ArticleDOI
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Qianghu Wang,Baoli Hu,Xin Hu,Xin Hu,Hoon Kim,Massimo Squatrito,Lisa Scarpace,Ana C. deCarvalho,Sali Lyu,Pengping Li,Yan Li,Floris P. Barthel,Hee Jin Cho,Hee Jin Cho,Yu Hsi Lin,Nikunj Satani,Emmanuel Martinez-Ledesma,Siyuan Zheng,Edward I. Chang,Charles Etienne Gabriel Sauvé,Adriana Olar,Zheng D. Lan,Gaetano Finocchiaro,Joanna J. Phillips,Mitchel S. Berger,Konrad Gabrusiewicz,Guocan Wang,Eskil Eskilsson,Jian Hu,Tom Mikkelsen,Ronald A. DePinho,Florian L. Muller,Amy B. Heimberger,Erik P. Sulman,Do Hyun Nam,Do Hyun Nam,Roel G.W. Verhaak +36 more
TL;DR: Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence within weeks of diagnosis and at recurrence.
Journal ArticleDOI
Genetics and biology of prostate cancer.
TL;DR: Improved disease management will also benefit from artificial intelligence-based expert decision support systems for proper standard of care, prognostic determinant biomarkers to minimize overtreatment of localized disease, and new standards of care accelerated by next-generation adaptive clinical trials.
Journal ArticleDOI
Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
Guocan Wang,Xin Lu,Prasenjit Dey,Pingna Deng,Chia Chin Wu,Shan Jiang,Zhuangna Fang,Kun Zhao,Ramakrishna Konaparthi,Sujun Hua,Jianhua Zhang,Elsa M. Li-Ning-Tapia,Avnish Kapoor,Chang-Jiun Wu,Neelay Bhaskar Patel,Zhenglin Guo,Vandhana Ramamoorthy,Trang N. Tieu,Timothy P. Heffernan,Di Zhao,Xiaoying Shang,Sunada Khadka,Pingping Hou,Baoli Hu,Eun Jung Jin,Wantong Yao,Xiaolu Pan,Zhihu Ding,Yanxia Shi,Liren Li,Qing Chang,Patricia Troncoso,Christopher J. Logothetis,Mark J. McArthur,Lynda Chin,Y. Alan Wang,Ronald A. DePinho +36 more
TL;DR: A critical role of MDSCs in prostate tumor progression is demonstrated and a cancer cell nonautonomous function of the Hippo-YAP pathway in regulation of CXCL5, a ligand for CXCR2-expressing M DSCs is discovered.
Journal ArticleDOI
Skp2 targeting suppresses tumorigenesis by Arf-p53- independent cellular senescence
Hui Kuan Lin,Zhenbang Chen,Zhenbang Chen,Zhenbang Chen,Guocan Wang,Caterina Nardella,Caterina Nardella,Szu Wei Lee,Chan Hsin Chan,Wei Lei Yang,Jing Wang,Ainara Egia,Keiichi I. Nakayama,Carlos Cordon-Cardo,Julie Teruya-Feldstein,Pier Paolo Pandolfi,Pier Paolo Pandolfi +16 more
TL;DR: It is shown that although Skp2 inactivation on its own does not induce cellular senescence, aberrant proto-oncogenic signals as well as inactivation of tumour suppressor genes do trigger a potent, tumour-suppressivesenescence response in mice and cells devoid of Skp1.
Journal ArticleDOI
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer
Wenting Liao,Michael J. Overman,Adam T. Boutin,Xiaoying Shang,Di Zhao,Prasenjit Dey,Jiexi Li,Guocan Wang,Zhengdao Lan,Jun Li,Ming Tang,Shan Jiang,Xingdi Ma,Peiwen Chen,Riham Katkhuda,Krittiya Korphaisarn,Deepavali Chakravarti,Andrew Chang,Denise J. Spring,Qing Chang,Jianhua Zhang,Dipen M. Maru,Dean Y. Maeda,John A. Zebala,Scott Kopetz,Y. Alan Wang,Ronald A. DePinho +26 more
TL;DR: The KRAS∗-IRF2-CXCL3- CXCR2 axis provides a framework for patient selection and combination therapies to enhance the effectiveness of ICB therapy in CRC and shows increased responsiveness to anti-PD-1 therapy.