E
Emmanuel Martinez-Ledesma
Researcher at Monterrey Institute of Technology and Higher Education
Publications - 34
Citations - 3056
Emmanuel Martinez-Ledesma is an academic researcher from Monterrey Institute of Technology and Higher Education. The author has contributed to research in topics: Glioma & Cancer. The author has an hindex of 13, co-authored 32 publications receiving 2114 citations. Previous affiliations of Emmanuel Martinez-Ledesma include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Qianghu Wang,Baoli Hu,Xin Hu,Xin Hu,Hoon Kim,Massimo Squatrito,Lisa Scarpace,Ana C. deCarvalho,Sali Lyu,Pengping Li,Yan Li,Floris P. Barthel,Hee Jin Cho,Hee Jin Cho,Yu Hsi Lin,Nikunj Satani,Emmanuel Martinez-Ledesma,Siyuan Zheng,Edward I. Chang,Charles Etienne Gabriel Sauvé,Adriana Olar,Zheng D. Lan,Gaetano Finocchiaro,Joanna J. Phillips,Mitchel S. Berger,Konrad Gabrusiewicz,Guocan Wang,Eskil Eskilsson,Jian Hu,Tom Mikkelsen,Ronald A. DePinho,Florian L. Muller,Amy B. Heimberger,Erik P. Sulman,Do Hyun Nam,Do Hyun Nam,Roel G.W. Verhaak +36 more
TL;DR: Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence within weeks of diagnosis and at recurrence.
Journal ArticleDOI
SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis
Raul Aguirre-Gamboa,Hugo Gomez-Rueda,Emmanuel Martinez-Ledesma,Antonio Martinez-Torteya,Rafael Chacolla-Huaringa,Alberto Rodriguez-Barrientos,Jose Tamez-Pena,Victor Trevino +7 more
TL;DR: This work developed SurvExpress, a cancer-wide gene expression database with clinical outcomes and a web-based tool that provides survival analysis and risk assessment of cancer datasets and shows the utility and simplicity of SurvExpress in two biomarker applications for breast and lung cancer.
Journal ArticleDOI
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Floris P. Barthel,Wei Wei,Ming Tang,Emmanuel Martinez-Ledesma,Xin Hu,Xin Hu,Samirkumar B. Amin,Samirkumar B. Amin,Kadir C. Akdemir,Sahil Seth,Xingzhi Song,Qianghu Wang,Tara M. Lichtenberg,Jian Hu,Jianhua Zhang,Siyuan Zheng,Roel G.W. Verhaak +16 more
TL;DR: This analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomere length in cancer.
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TumorFusions: An integrative resource for cancer-associated transcript fusions
Xin Hu,Xin Hu,Qianghu Wang,Ming Tang,Floris P. Barthel,Samirkumar B. Amin,Kosuke Yoshihara,Frederick Lang,Emmanuel Martinez-Ledesma,Soo Hyun Lee,Siyuan Zheng,Roel G.W. Verhaak +11 more
TL;DR: TumorFusions is described, a data portal that catalogues 20 731 gene fusions detected in 9966 well characterized cancer samples and 648 normal specimens from The Cancer Genome Atlas (TCGA), which spans 33 cancer types in TCGA.
Journal ArticleDOI
Erratum: Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment (Cancer Cell (2017) 32(1) (42–56.e6)(S1535610817302532)(10.1016/j.ccell.2017.06.003))
Qianghu Wang,Baoli Hu,Xin Hu,Hoon Kim,Massimo Squatrito,Lisa Scarpace,Ana C. deCarvalho,Sali Lyu,Pengping Li,Yan Li,Floris P. Barthel,Hee Jin Cho,Yu Hsi Lin,Nikunj Satani,Emmanuel Martinez-Ledesma,Siyuan Zheng,Edward F. Chang,Charles Etienne Gabriel Sauvé,Adriana Olar,Zheng D. Lan,Gaetano Finocchiaro,Joanna J. Phillips,Mitchel S. Berger,Konrad Gabrusiewicz,Guocan Wang,Eskil Eskilsson,Jian Hu,Tom Mikkelsen,Ronald A. DePinho,Florian L. Muller,Amy B. Heimberger,Erik P. Sulman,Do-Hyun Nam,Roel G.W. Verhaak +33 more