N
Nikunj Satani
Researcher at University of Texas Health Science Center at Houston
Publications - 34
Citations - 2158
Nikunj Satani is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Stroke & Enolase. The author has an hindex of 13, co-authored 29 publications receiving 1428 citations. Previous affiliations of Nikunj Satani include University of Texas Health Science Center at San Antonio & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Qianghu Wang,Baoli Hu,Xin Hu,Xin Hu,Hoon Kim,Massimo Squatrito,Lisa Scarpace,Ana C. deCarvalho,Sali Lyu,Pengping Li,Yan Li,Floris P. Barthel,Hee Jin Cho,Hee Jin Cho,Yu Hsi Lin,Nikunj Satani,Emmanuel Martinez-Ledesma,Siyuan Zheng,Edward I. Chang,Charles Etienne Gabriel Sauvé,Adriana Olar,Zheng D. Lan,Gaetano Finocchiaro,Joanna J. Phillips,Mitchel S. Berger,Konrad Gabrusiewicz,Guocan Wang,Eskil Eskilsson,Jian Hu,Tom Mikkelsen,Ronald A. DePinho,Florian L. Muller,Amy B. Heimberger,Erik P. Sulman,Do Hyun Nam,Do Hyun Nam,Roel G.W. Verhaak +36 more
TL;DR: Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence within weeks of diagnosis and at recurrence.
Journal ArticleDOI
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Prasenjit Dey,Joelle Baddour,Florian L. Muller,Chia Chin Wu,Huamin Wang,Wen Ting Liao,Zangdao Lan,Alina Chen,Tony Gutschner,Ya'an Kang,Jason B. Fleming,Nikunj Satani,Di Zhao,Abhinav Achreja,Lifeng Yang,Jiyoon Lee,Edward F. Chang,Giannicola Genovese,Andrea Viale,Haoqiang Ying,Giulio Draetta,Anirban Maitra,Y. Alan Wang,Deepak Nagrath,Ronald A. DePinho +24 more
TL;DR: In this paper, the authors show that ME3 depletion selectively kills ME2-null PDAC cells in a manner consistent with an essential function for ME3 in ME2−null cancer cells.
Journal ArticleDOI
Erratum: Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment (Cancer Cell (2017) 32(1) (42–56.e6)(S1535610817302532)(10.1016/j.ccell.2017.06.003))
Qianghu Wang,Baoli Hu,Xin Hu,Hoon Kim,Massimo Squatrito,Lisa Scarpace,Ana C. deCarvalho,Sali Lyu,Pengping Li,Yan Li,Floris P. Barthel,Hee Jin Cho,Yu Hsi Lin,Nikunj Satani,Emmanuel Martinez-Ledesma,Siyuan Zheng,Edward F. Chang,Charles Etienne Gabriel Sauvé,Adriana Olar,Zheng D. Lan,Gaetano Finocchiaro,Joanna J. Phillips,Mitchel S. Berger,Konrad Gabrusiewicz,Guocan Wang,Eskil Eskilsson,Jian Hu,Tom Mikkelsen,Ronald A. DePinho,Florian L. Muller,Amy B. Heimberger,Erik P. Sulman,Do-Hyun Nam,Roel G.W. Verhaak +33 more
Journal ArticleDOI
The intricate mechanisms of neurodegeneration in prion diseases
Claudio Soto,Nikunj Satani +1 more
TL;DR: The pathways implicated in prion-induced brain damage are reviewed and the pieces are put together into a possible model of neurodegeneration in prions disorders to develop a much needed therapy for these devastating diseases.
Journal ArticleDOI
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Rina M. Mbofung,Jodi A. McKenzie,Shruti Malu,Min Zhang,Weiyi Peng,Chengwen Liu,Isere Kuiatse,Trang N. Tieu,Leila Williams,Seram Devi,Emily Ashkin,Chunyu Xu,Lu Huang,Minying Zhang,Amjad H. Talukder,Satyendra C. Tripathi,Hiep Khong,Nikunj Satani,Florian L. Muller,Jason Roszik,Timothy P. Heffernan,James P. Allison,Gregory Lizée,Sam Hanash,David A. Proia,Rodabe N. Amaria,R. Eric Davis,Patrick Hwu +27 more
TL;DR: It is shown that inhibition of HSP90 with ganetespib enhances T-cell-mediated killing of patient-derived human melanoma cells by their autologous T cells in vitro and potentiates responses to anti-CTLA4 and anti-PD1 therapy in vivo.