Y
Yan Wen
Researcher at National Health and Family Planning Commission
Publications - 147
Citations - 1562
Yan Wen is an academic researcher from National Health and Family Planning Commission. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 13, co-authored 102 publications receiving 994 citations. Previous affiliations of Yan Wen include Xi'an Jiaotong University.
Papers
More filters
Journal ArticleDOI
CRISPR/Cas9 for genome editing: progress, implications and challenges
Feng Zhang,Yan Wen,Xiong Guo +2 more
TL;DR: The molecular mechanism, applications and challenges of CRISPR/Cas9-mediated genome editing and clinical therapeutic potential ofCRISPR-associated protein 9 are reviewed and a protospacer adjacent motif locating at downstream of target sequences is reviewed.
Journal ArticleDOI
Identifying psychiatric disorder-associated gut microbiota using microbiota-related gene set enrichment analysis
Shiqiang Cheng,Bei Han,Miao Ding,Yan Wen,Mei Ma,Lu Zhang,Xin Qi,Bolun Cheng,Ping Li,Om Prakash Kafle,Xiao Liang,Li Liu,Yanan Du,Yan Zhao,Feng Zhang +14 more
TL;DR: The classic gene set enrichment analysis (GSEA) approach was extended to detect the association between gut microbiota and complex diseases using published genome-wide association study (GWAS) and GWAS of gut microbiota summary data and identified several significant associations between psychiatric disorders and gut microbiota.
Journal ArticleDOI
Socioeconomic Deprivation Index Is Associated With Psychiatric Disorders: An Observational and Genome-wide Gene-by-Environment Interaction Analysis in the UK Biobank Cohort.
Jing Ye,Yan Wen,Xifang Sun,Xiaomeng Chu,Ping Li,Bolun Cheng,Shiqiang Cheng,Li Liu,Lu Zhang,Mei Ma,Xin Qi,Chujun Liang,Om Prakash Kafle,Yumeng Jia,Cuiyan Wu,Sen Wang,Xi Wang,Yujie Ning,Shiquan Sun,Feng Zhang +19 more
TL;DR: The genome-wide gene-by-environment interaction study identified several candidate genes interacting with the TDI, providing novel clues for understanding the biological mechanism of associations between the TDI and psychiatric disorders.
Journal ArticleDOI
Assessing the Relationship Between Gut Microbiota and Bone Mineral Density.
Shiqiang Cheng,Xin Qi,Mei Ma,Lu Zhang,Bolun Cheng,Chujun Liang,Li Liu,Ping Li,Om Prakash Kafle,Yan Wen,Feng Zhang +10 more
TL;DR: The study findings support the weak relevance of gut microbiota with the development of BMD by showing suggestive association signal with gut microbiota after multiple testing correction.
Journal ArticleDOI
A Genome-wide Expression Association Analysis Identifies Genes and Pathways Associated with Amyotrophic Lateral Sclerosis.
Yanan Du,Yan Wen,Xiong Guo,Jingcan Hao,Wenyu Wang,Awen He,Qianrui Fan,Ping Li,Li Liu,Xiao Liang,Feng Zhang +10 more
TL;DR: This study conducted a genome-wide expression association analysis by summary data-based Mendelian randomization (SMR) method and identified one significant and four suggestive genes associated with ALS, providing novel clues for the genetic mechanism studies of ALS.