Y
Yan Zhang
Researcher at Central South University
Publications - 246
Citations - 4815
Yan Zhang is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 31, co-authored 191 publications receiving 3210 citations. Previous affiliations of Yan Zhang include Huazhong University of Science and Technology & Changsha Medical University.
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Journal ArticleDOI
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
Xiling Liu,Mehmet Somel,Mehmet Somel,Lin Tang,Zheng Yan,Xi Jiang,Song Guo,Yuan Yuan,Liu He,Anna Oleksiak,Yan Zhang,Na Li,Yuhui Hu,Wei Chen,Zilong Qiu,Svante Pääbo,Philipp Khaitovich,Philipp Khaitovich +17 more
TL;DR: It is shown that the most prominent human-specific expression change affects genes associated with synaptic functions and represents an extreme shift in the timing of synaptic development in the prefrontal cortex, but not the cerebellum.
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Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect
Lifeng Wang,Zhengjia Dai,Hongjun Peng,Liwen Tan,Yu-Qiang Ding,Yu-Qiang Ding,Zhong He,Yan Zhang,Mingrui Xia,Zexuan Li,Weihui Li,Yi Cai,Shaojia Lu,Mei Liao,Li Zhang,Weiwei Wu,Yong He,Lingjiang Li +17 more
TL;DR: It was showed that the MDD groups with and without childhood neglect exhibited overlapping and segregated functional connectivity patterns in the whole‐brain networks, providing empirical evidence for the contribution of early life stress to the pathophysiology of MDD.
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Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study
Jin Lu,Xiufeng Xu,Yueqin Huang,Tao Li,Chao Ma,Guangming Xu,Huifang Yin,Xiangdong Xu,Yanjuan Ma,Limin Wang,Zhengjing Huang,Yongping Yan,Bo Wang,Shuiyuan Xiao,Liang Zhou,Lingjiang Li,Yan Zhang,Hongguang Chen,Tingting Zhang,Jie Yan,Hua Ding,Yaqin Yu,Changgui Kou,Zonglin Shen,Linling Jiang,Linling Jiang,Zhizhong Wang,Xian Sun,Yifeng Xu,Yanling He,Wanjun Guo,Lijun Jiang,Lijun Jiang,Shengyan Li,Wen Pan,Yue Wu,Guohua Li,Fu-Jun Jia,Jianfei Shi,Zhongxia Shen,Ning Zhang +40 more
TL;DR: Wang et al. as discussed by the authors used the Composite International Diagnostic Interview 3.0 to ascertain the presence of lifetime and 12-month depressive disorders according to DSM-IV criteria, including major depressive disorder, dysthymic disorder and depressive disorder not otherwise specified.
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From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder
TL;DR: The evidence challenging the monoamine hypothesis is summarized and proposed that the antidepressant efficacy of SSRIs is not derived from elevated monoamine (5-HT, noradrenaline (NE), or dopamine (DA) concentration or monoamine neurotransmission.
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The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling
TL;DR: Observations indicate that MeCP2 mediates activity-dependent synaptic scaling, and suggest that the pathophysiology of Rett syndrome, which is caused by mutations in Me CP2, may involve defects in activity- dependent regulation of synaptic currents.