Y
Yuhui Hu
Researcher at Southern University of Science and Technology
Publications - 42
Citations - 1984
Yuhui Hu is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 16, co-authored 37 publications receiving 1636 citations. Previous affiliations of Yuhui Hu include Hong Kong Baptist University & CAS-MPG Partner Institute for Computational Biology.
Papers
More filters
Journal ArticleDOI
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
Mehmet Somel,Song Guo,Ning Fu,Zheng Yan,Haiyang Hu,Ying Xu,Yuan Yuan,Zhibin Ning,Yuhui Hu,Corinna Menzel,Hao Hu,Michael Lachmann,Rong Zeng,Wei Chen,Philipp Khaitovich +14 more
TL;DR: Surprisingly, many gene expression changes previously attributed to aging, such as down-regulation of neural genes, initiate in early childhood, suggesting a direct link between developmental regulation and expression changes taking place in aging.
Journal ArticleDOI
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
Xiling Liu,Mehmet Somel,Mehmet Somel,Lin Tang,Zheng Yan,Xi Jiang,Song Guo,Yuan Yuan,Liu He,Anna Oleksiak,Yan Zhang,Na Li,Yuhui Hu,Wei Chen,Zilong Qiu,Svante Pääbo,Philipp Khaitovich,Philipp Khaitovich +17 more
TL;DR: It is shown that the most prominent human-specific expression change affects genes associated with synaptic functions and represents an extreme shift in the timing of synaptic development in the prefrontal cortex, but not the cerebellum.
Journal ArticleDOI
MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates
Mehmet Somel,Xiling Liu,Lin Tang,Zheng Yan,Haiyang Hu,Song Guo,Xi Jiang,Xiaoyu Zhang,Guohua Xu,Gangcai Xie,Gangcai Xie,Na Li,Yuhui Hu,Wei Chen,Wei Chen,Svante Pääbo,Philipp Khaitovich +16 more
TL;DR: Comparison of human, chimpanzee, and macaque brain transcriptomes reveals a significant developmental remodeling in the human prefrontal cortex, potentially shaped by microRNA.
Journal ArticleDOI
Widespread expression of piRNA-like molecules in somatic tissues
Zheng Yan,Haiyang Hu,Xi Jiang,Vera Maierhofer,Elena Neb,Liu He,Yuhui Hu,Hao Hu,Na Li,Wei Chen,Philipp Khaitovich,Philipp Khaitovich +11 more
TL;DR: The results show widespread presence of pilRNA, displaying all known characteristics of piRNA in multiple somatic tissues of these three species, and indicate that piRNA-like molecules might play important roles outside of the germline.
Journal ArticleDOI
Widespread splicing changes in human brain development and aging
Pavel V. Mazin,Pavel V. Mazin,Jieyi Xiong,Xiling Liu,Zheng Yan,Xiaoyu Zhang,Xiaoyu Zhang,Mingshuang Li,Mingshuang Li,Liu He,Mehmet Somel,Mehmet Somel,Yuan Yuan,Yuan Yuan,Yi-Ping Phoebe Chen,Na Li,Yuhui Hu,Ning Fu,Zhibin Ning,Rong Zeng,Hongyi Yang,Wei Chen,Wei Chen,Mikhail S. Gelfand,Philipp Khaitovich,Philipp Khaitovich +25 more
TL;DR: Across lifespan, splicing changes followed discrete patterns that could be linked to neural functions, and associated with the expression profiles of the corresponding splicing factors, and were abundant in both of the brain regions studied.