Y
Yanan Wang
Researcher at Nanjing Medical University
Publications - 5
Citations - 73
Yanan Wang is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: CD34 & Haematopoiesis. The author has an hindex of 4, co-authored 5 publications receiving 64 citations. Previous affiliations of Yanan Wang include Wadsworth Center.
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Journal ArticleDOI
Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice.
Lei Li,Sarah A. Carratt,Matthew Hartog,Nataliia Kovalchuk,Kunzhi Jia,Yanan Wang,Qing Yu Zhang,Patricia C. Edwards,Laura S. Van Winkle,Xinxin Ding +9 more
TL;DR: In vitro studies indicated that the NA bioactivation activities in OM and lung of the CYP2A13/2F1-humanized mice were primarily contributed by, respectively, CYP 2A13 and CYF1.
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Safety and Efficacy of Megakaryocytes Induced from Hematopoietic Stem Cells in Murine and Nonhuman Primate Models.
Xin Guan,Meng Qin,Yu Zhang,Yanan Wang,Bin Shen,Zhihua Ren,Xinxin Ding,Xinxin Ding,Wei Dai,Wei Dai,Yongping Jiang +10 more
TL;DR: The development of an efficient two‐stage culture system that is free of stroma, animal components, and genetic manipulations for the production of functional megakaryocytes from hematopoietic stem cells is reported, suggesting that large‐scale induction of functionalmegakaryocytic cells is applicable for treating thrombocytopenic blood diseases in the clinic.
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Anti-tumor effect of a novel soluble recombinant human endostatin: administered as a single agent or in combination with chemotherapy agents in mouse tumor models.
TL;DR: Soluble rhEndostatin exhibits a potent anti-tumor activity in mouse xenograft models and it also has an additive effect with CTX and DDP, implying possible applications in clinical settings.
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Preferential expression of cytochrome CYP CYP2R1 but not CYP1B1 in human cord blood hematopoietic stem and progenitor cells
TL;DR: Findings provide the basis for further studies on possible functions of CYP2R1 and CYP1B1 in CBHSPCs proliferation and/or differentiation and their potential utility as targets for drugs designed to modulate CD34+CBHSPC expansion or differentiation.
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Role of human CYP2A13 and CYP2F1 in naphthalene bioactivation and toxicity in the lung and nasal mucosa of a CYP2A13/2F1-humanized Mouse (LB636)
TL;DR: In vitro studies indicated that CYP2A13/2F1-humanized mice showed greater sensitivity than Cyp2abfgs-null mice did, to NA-induced depleti...