Y
Yongping Jiang
Researcher at Peking Union Medical College
Publications - 37
Citations - 455
Yongping Jiang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 12, co-authored 37 publications receiving 355 citations.
Papers
More filters
Journal ArticleDOI
Large-Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells
Yu Zhang,Chen Wang,Lan Wang,Bin Shen,Xin Guan,Jing Tian,Zhihua Ren,Xinxin Ding,Yupo Ma,Yupo Ma,Wei Dai,Wei Dai,Yongping Jiang +12 more
TL;DR: It is reported that functional human erythrocytes can be efficiently produced from cord blood (CB) CD34+ cells using a bottle turning device culture system and suggested that the ex vivo‐generated ery Throcytes could be an alternative blood source for traditional transfusion products in the clinic.
Journal ArticleDOI
In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library
TL;DR: An in vivo SELEX in mice using a PEGylated RNA library for the identification of a 2′-F RNA aptamer (RA16) that specifically binds to NCI-H460 non-small-cell lung cancer cells with an affinity (KD) of 9 ± 2 nM is reported.
Journal ArticleDOI
Sumoylation is important for stability, subcellular localization and transcriptional activity of Sall4, an essential stem cell transcription factor
TL;DR: Combined studies reveal sumoylation as a novel form of post-translational modification for regulating the stability, subcellular localization, and transcriptional activity of SALL4.
Journal ArticleDOI
A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation
Lan Wang,Xin Guan,Huihui Wang,Bin Shen,Yu Zhang,Zhihua Ren,Yupo Ma,Yupo Ma,Xinxin Ding,Xinxin Ding,Yongping Jiang +10 more
TL;DR: An optimal small-molecule/cytokine combination for the enhancement of HSC expansion via inhibition of differentiation is developed and indicates promising application for preparation of both the HSCs and the mature, functional hematopoietic cells for clinical transplantation.
Journal ArticleDOI
Histone Lysine-specific Demethylase 1 (LSD1) Protein Is Involved in Sal-like Protein 4 (SALL4)-mediated Transcriptional Repression in Hematopoietic Stem Cells
Li Liu,Joseph Souto,Wenbin Liao,Yongping Jiang,Yangqiu Li,Ryuichi Nishinakamura,Suming Huang,Todd K. Rosengart,Vincent W. Yang,Michael W. Schuster,Yupo Ma,Yupo Ma,Jianchang Yang +12 more
TL;DR: The data revealed that histone demethylase LSD1 may negatively regulate SALL4-mediated transcription, and the dynamic regulation of Sall4-associated epigenetic factors cooperatively modulates early hematopoietic precursor proliferation.