Yanfen Yang

TL;DR: A pivotal role for IL-33 is demonstrated in driving primary and anamnestic immunity against the rodent hookworm Nippostrongylus brasiliensis and impairs resistin-like molecule beta (RELMβ) expression and eosinophil recruitment, which are two mechanisms that eliminate N. Brasiliensis parasites from infected hosts.

TL;DR: Using a mouse model of allergic asthma, it is demonstrated that blockade of PD‐1/PD‐L1 has distinct influences on different CD4+ T‐cell subsets, which suggests that severe allergic asthma may be associated with a defective PD‐ 1/PD-L1 regulatory axis in some individuals.

TL;DR: IL‐17A contributes to asthma pathophysiology by increasing the capacity of IL‐13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6 activation.

TL;DR: It is found that human TLR5 seems to be the evolutionarily closest member of the TLR gene family to mouse tlr11, and a previously unappreciated cross-recognition of a relevant human pathogen-derived pathogenic-associated molecular pattern is revealed.

TL;DR: In this article, the role of trefoil factor 2 (TFF2) was investigated in the protection of host against Toxoplasma gondii infection in mice, and it was shown that TFF2 regulated intestinal barrier function and type 1 cytokine release from myeloid phagocytes.