D
David Wu
Researcher at University of Washington
Publications - 86
Citations - 3753
David Wu is an academic researcher from University of Washington. The author has contributed to research in topics: Minimal residual disease & Population. The author has an hindex of 23, co-authored 82 publications receiving 2814 citations. Previous affiliations of David Wu include Harvard University & University of Washington Medical Center.
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Journal ArticleDOI
Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
Rebecca Gardner,David Wu,Sindhu Cherian,Min Fang,Laïla Aïcha Hanafi,Olivia Finney,Hannah Smithers,Michael C. Jensen,Stanley R. Riddell,Stanley R. Riddell,David G. Maloney,David G. Maloney,Cameron J. Turtle,Cameron J. Turtle +13 more
TL;DR: Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies.
Journal ArticleDOI
Using synthetic templates to design an unbiased multiplex PCR assay
Christopher S. Carlson,Ryan O. Emerson,Anna Sherwood,Cindy Desmarais,Moon Chung,Joseph M. Parsons,Michelle S. Steen,Marissa A. LaMadrid-Herrmannsfeldt,David Williamson,Robert J. Livingston,David Wu,Brent L. Wood,Mark J. Rieder,Harlan Robins +13 more
TL;DR: A multiplex PCR with a mixture of primers targeting the rearranged variable and joining segments to capture receptor diversity is applied to a multiplex T cell receptor gamma sequencing assay and can be extended to any adaptive immune locus.
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International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease
David C. Fajgenbaum,Thomas S. Uldrick,Adam Bagg,Dale Frank,David Wu,Gordan Srkalovic,David Simpson,Amy Y. Liu,David M. Menke,Shanmuganathan Chandrakasan,Mary Jo Lechowicz,Raymond S.M. Wong,Sheila K Pierson,Michele Paessler,Jean François Rossi,Makoto Ide,Jason R. Ruth,Michael P. Croglio,Alexander Suarez,Vera P. Krymskaya,Amy Chadburn,Gisele W. B. Colleoni,Sunita D. Nasta,Raj Jayanthan,Christopher S. Nabel,Corey Casper,Angela Dispenzieri,Alexander Fosså,Dermot Kelleher,Razelle Kurzrock,Peter M. Voorhees,Ahmet Dogan,Kazuyuki Yoshizaki,Frits van Rhee,Eric Oksenhendler,Elaine S. Jaffe,Kojo S.J. Elenitoba-Johnson,Megan S. Lim +37 more
TL;DR: The proposed consensus criteria will facilitate consistent diagnosis, appropriate treatment, and collaborative research and exclude infectious, malignant, and autoimmune disorders that can mimic iMCD.
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Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens.
Colin C. Pritchard,Stephen J. Salipante,Karen M. Koehler,Christina Smith,Sheena M. Scroggins,Brent L. Wood,David Wu,Ming K. Lee,Suzanne M. Dintzis,Andrew Adey,Yajuan Liu,Keith D. Eaton,Renato G. Martins,Kari Stricker,Kim Margolin,Noah G. Hoffman,Jane E. Churpek,Jonathan F. Tait,Mary Claire King,Tom Walsh +19 more
TL;DR: UW-OncoPlex is developed, a clinical molecular diagnostic assay to provide simultaneous deep-sequencing information, based on >500× average coverage, for all classes of mutations in 194 clinically relevant genes, to best guide existing and emerging treatment regimens and facilitate integration of genomic testing with patient care.
Journal ArticleDOI
High-Throughput Sequencing Detects Minimal Residual Disease in Acute T Lymphoblastic Leukemia
David Wu,Anna Sherwood,Jonathan R. Fromm,Stuart S. Winter,Kimberly P. Dunsmore,Mignon L. Loh,Harvey A. Greisman,Daniel E. Sabath,Brent L. Wood,Harlan Robins +9 more
TL;DR: Next-generation sequencing of lymphoid receptor gene repertoire may improve clinical diagnosis and subsequent MRD monitoring of lymphoproliferative disorders and lower the threshold of detection for MRD and affect treatment decisions.