Yanyan Sun

TL;DR: Repeated systemic exposure to the TLR2 agonist Pam3CSK4 can have a short-term negative impact on the neonatal mouse brain, although long-term memory function and the volume of gray or white matter are not affected.

TL;DR: Findings reveal that selective neuronal deletion of Atg7 is strongly protective against neuronal death and overall brain injury occurring after HI and suggest that inhibition of HI-enhanced autophagy should be considered as a potential therapeutic target for the treatment of human newborns developing severe hypoxic-ischemic encephalopathy.

TL;DR: Lithium conferred impressive, morphological long-term protection against neonatal HI, at least partly by inhibiting inflammation and promoting NSPC proliferation and survival.

TL;DR: Lithium administration could decrease IR-induced neural progenitor cell apoptosis in the GCL of the hippocampus and ameliorate learning impairments and it remains to be shown if lithium can be used to prevent the debilitating cognitive late effects seen in children treated with cranial radiotherapy.

TL;DR: This study found that irradiation-induced cell death occurred mainly in the external germinal layer (EGL) of the juvenile rat cerebellum, and Interestingly, blood-brain barrier damage and blood flow reduction was considerably more pronounced in the Cerebellum compared to other brain regions.