Yao Chen

TL;DR: It is shown that these inhibitors produce rapid and dramatic changes in a brain lipid signaling network, comprising not only 2-AG, but also eicosanoids and diacylglycerols, underscoring the broad role that DAGLs play in nervous system metabolism and function.

TL;DR: The current understanding of CD8 T cell differentiation upon acute infection is summarized, with a focus on the transcriptional and epigenetic regulation of cell fate decision and memory formation.

TL;DR: In this paper, the authors identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and TRM cells, and termed these cells as resident helper T (TRH) cells.

TL;DR: A critical role for Tfh-derived IL-10 in promoting humoral immunity during persistent viral infection is elucidated and single cell RNA sequencing is used to interrogate the IL10 CD4+ T cell compartment in a murine model of chronic infection and identify Il10-producing TfH involved in promotion of the antiviral humoral immune response.

TL;DR: Cui et al. as discussed by the authors identify distinct gene regulatory networks and epigenetic landscapes underpinning the formation of these subsets, and further identify a previously unappreciated role for the transcription factor BATF in maintaining a permissive chromatin structure that allows the transition from TCF-1+ progenitors to CX3CR1+ effector cells.