M
Marc P. Baggelaar
Researcher at Leiden University
Publications - 29
Citations - 1187
Marc P. Baggelaar is an academic researcher from Leiden University. The author has contributed to research in topics: Diacylglycerol lipase & Diacylglycerol kinase. The author has an hindex of 14, co-authored 25 publications receiving 913 citations. Previous affiliations of Marc P. Baggelaar include University of Groningen & Imperial College London.
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Journal ArticleDOI
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Marjolein Soethoudt,Uwe Grether,Juergen Fingerle,Travis W. Grim,Filomena Fezza,Luciano De Petrocellis,Christoph Ullmer,Benno Rothenhäusler,Camille Perret,Noortje van Gils,David B. Finlay,Christa MacDonald,Andrea Chicca,Marianela Dalghi Gens,Jordyn Stuart,Henk de Vries,Nicolina Mastrangelo,Lizi Xia,Georgios Alachouzos,Marc P. Baggelaar,Andrea Martella,Elliot D. Mock,Hui Deng,Laura H. Heitman,Mark Connor,Vincenzo Di Marzo,Jürg Gertsch,Aron H. Lichtman,Mauro Maccarrone,Pal Pacher,Michelle Glass,Mario van der Stelt +31 more
TL;DR: The most extensive characterization of the molecular pharmacology of the most widely used CB2R ligands to date is reported, identifying marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects.
Journal ArticleDOI
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Annelot C. M. van Esbroeck,Antonius P A Janssen,Armand B. Cognetta,Daisuke Ogasawara,Guy Shpak,Mark van der Kroeg,Vasudev Kantae,Marc P. Baggelaar,Femke M.S. de Vrij,Hui Deng,Marco Allarà,Filomena Fezza,Zhanmin Lin,Tom van der Wel,Marjolein Soethoudt,Elliot D. Mock,Hans den Dulk,Ilse L. Baak,Bogdan I. Florea,Giel Hendriks,Luciano De Petrocellis,Herman S. Overkleeft,Thomas Hankemeier,Chris I. De Zeeuw,Chris I. De Zeeuw,Vincenzo Di Marzo,Mauro Maccarrone,Benjamin F. Cravatt,Steven A. Kushner,Mario van der Stelt +29 more
TL;DR: Analysis of the protein interaction landscape of BIA 10-2474 in human cells and tissues revealed that the drug inhibits several lipases that are not targeted by PF04457845, a highly selective and clinically tested FAAH inhibitor.
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2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain
TL;DR: The biosynthetic and metabolic pathways of 2-AG are described and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid.
Journal ArticleDOI
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
Daisuke Ogasawara,Hui Deng,Andreu Viader,Marc P. Baggelaar,Arjen C. Breman,Hans den Dulk,Adrianus M. C. H. van den Nieuwendijk,Marjolein Soethoudt,Tom van der Wel,Juan Zhou,Herman S. Overkleeft,Manuel Sanchez-Alavez,Simone Mori,William Nguyen,Bruno Conti,Xiaojie Liu,Yao Chen,Qing-song Liu,Benjamin F. Cravatt,Mario van der Stelt +19 more
TL;DR: It is shown that these inhibitors produce rapid and dramatic changes in a brain lipid signaling network, comprising not only 2-AG, but also eicosanoids and diacylglycerols, underscoring the broad role that DAGLs play in nervous system metabolism and function.
Journal ArticleDOI
Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain†
Marc P. Baggelaar,Freek J. Janssen,Annelot C. M. van Esbroeck,Hans den Dulk,Marco Allarà,Sascha Hoogendoorn,Ross McGuire,Bogdan I. Florea,Nico J. Meeuwenoord,Hans van den Elst,Gijsbert A. van der Marel,Jaap Brouwer,Vincenzo Di Marzo,Herman S. Overkleeft,Mario van der Stelt +14 more