Y
Yao Fan
Researcher at Argonne National Laboratory
Publications - 12
Citations - 332
Yao Fan is an academic researcher from Argonne National Laboratory. The author has contributed to research in topics: Quantum tunnelling & Protein crystallization. The author has an hindex of 7, co-authored 12 publications receiving 309 citations. Previous affiliations of Yao Fan include University of California, San Francisco & University of Minnesota.
Papers
More filters
Journal ArticleDOI
Large-scale evaluation of protein reductive methylation for improving protein crystallization.
Youngchang Kim,Pearl Quartey,Hui Li,L. Volkart,C. Hatzos,Changsoo Chang,Boguslaw Nocek,Marianne E. Cuff,Jerzy Osipiuk,Kemin Tan,Yao Fan,Lance Bigelow,Natalia Maltseva,Ruiying Wu,Maria Borovilos,Erika Duggan,M. Zhou,T. Andrew Binkowski,Rongguang Zhang,Andrzej Joachimiak +19 more
TL;DR: Large-scale evaluation of protein reductive methylation for improving protein crystallization using Na6(CO3)(SO4)(SO3)2 as a surrogate for Na2CO3 in the presence of Na2SO4 in the absence of Na3SO4.
Journal ArticleDOI
Characterization of a Bacillus subtilis transporter for petrobactin, an anthrax stealth siderophore
Anna M. Zawadzka,Youngchang Kim,Natalia Maltseva,Rita Nichiporuk,Yao Fan,Andrzej Joachimiak,Kenneth N. Raymond +6 more
TL;DR: The yclNOPQ operon is shown to encode the complete transporter for petrobactin (PB), a photoreactive 3,4-catecholate siderophore produced by many members of the B. cereus group and likely contributors to the pathogenicity of these species and provide a potential target for antibacterial strategies.
Journal ArticleDOI
Connecting Protein Conformational Dynamics with Catalytic Function As Illustrated in Dihydrofolate Reductase
TL;DR: Combined quantum mechanics/molecular mechanics molecular dynamics simulations reveal that the M20 loop conformational dynamics of dihydrofolate reductase (DHFR) is severely restricted at the transition state of the hydride transfer as a result of the M42W/G121V double mutation.
Journal ArticleDOI
Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase.
TL;DR: High-resolution X-ray crystal structures of the dapE from Haemophilus influenzae with one and two zinc ions bound in the active site, respectively are reported and a revised catalytic mechanism of peptide bond cleavage by DapE enzymes is proposed.
Journal ArticleDOI
EsxB, a secreted protein from Bacillus anthracis forms two distinct helical bundles
Yao Fan,Kemin Tan,Kemin Tan,Gekleng Chhor,Emily K. Butler,Emily K. Butler,Robert Jedrzejczak,Dominique Missiakas,Dominique Missiakas,Andrzej Joachimiak,Andrzej Joachimiak +10 more
TL;DR: The crystal structures of recombinant EsxB are determined and it is discovered that the small protein, comprised of a helix‐loop‐helix (HLH) hairpin, is capable of associating into two different helical bundles.