K
Kemin Tan
Researcher at Argonne National Laboratory
Publications - 86
Citations - 4411
Kemin Tan is an academic researcher from Argonne National Laboratory. The author has contributed to research in topics: Protein structure & Ligand (biochemistry). The author has an hindex of 31, co-authored 79 publications receiving 3879 citations. Previous affiliations of Kemin Tan include Harvard University & Stony Brook University.
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Journal ArticleDOI
Atomic structure of a thermostable subdomain of HIV-1 gp41.
TL;DR: This thermostable subdomain displays the salient features of the core structure of the isolated gp41 subunit and thus provides a possible target for therapeutics designed selectively to block HIV-1 entry.
Journal ArticleDOI
The crystal structure of a T cell receptor in complex with peptide and MHC class II
Ellis L. Reinherz,Kemin Tan,Lei Tang,Petra Kern,Jin-huan Liu,Yi Xiong,Rebecca E. Hussey,Alex Smolyar,Brian Hare,Rongguang Zhang,Andrzej Joachimiak,Hsiu-Ching Chang,Gerhard Wagner,Jia-huai Wang +13 more
TL;DR: That docking is limited to one segment of MHC-bound peptide offers an explanation for epitope recognition and altered peptide ligand effects, suggests a structural basis for alloreactivity, and illustrates how bacterial superantigens can span the TCR-pMHCII surface.
Journal ArticleDOI
Crystal structure of the TSP-1 type 1 repeats a novel layered fold and its biological implication
Kemin Tan,Mark Duquette,Mark Duquette,Jin-huan Liu,Yicheng Dong,Rongguang Zhang,Andrzej Joachimiak,Jack Lawler,Jack Lawler,Jia-huai Wang +9 more
TL;DR: This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily.
Journal ArticleDOI
Structure of a Heterophilic Adhesion Complex between the Human CD2 and CD58 (LFA-3) Counterreceptors
Jia-huai Wang,Alex Smolyar,Kemin Tan,Jin-huan Liu,Mikyung Kim,Zhen-Yu J. Sun,Gerhard Wagner,Ellis L. Reinherz +7 more
TL;DR: The crystal structure of the heterophilic adhesion complex between the amino-terminal domains of human CD2 and CD58 is reported, explaining CD2-CD58 dynamic binding and offering insights into interactions of related immunoglobulin superfamily receptors.
Journal ArticleDOI
Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography
Jason R. Stagno,Yuan Liu,Yuba R. Bhandari,Chelsie E. Conrad,Subrata Panja,Monalisa Swain,Lixin Fan,Garrett Nelson,Chufeng Li,D.R. Wendel,Thomas A. White,Jesse Coe,Max O. Wiedorn,Juraj Knoska,Dominik Oberthuer,R.A. Tuckey,Ping Yu,Marzena A. Dyba,Sergey G. Tarasov,Uwe Weierstall,Thomas D. Grant,Charles D. Schwieters,Jiashan Zhang,Adrian R. Ferré-D'Amaré,Petra Fromme,D. E. Draper,Mengning Liang,Mark S. Hunter,Sébastien Boutet,Kemin Tan,Xiaobing Zuo,Xinhua Ji,Anton Barty,Nadia A. Zatsepin,Henry N. Chapman,John C. H. Spence,Sarah A. Woodson,Yun-Xing Wang +37 more
TL;DR: The potential of ‘mix-and-inject’ time-resolved serial crystallography to study biochemically important interactions between biomacromolecules and ligands, including those that involve large conformational changes, is demonstrated.