Y
Yao Sen Ko
Researcher at Chiba University
Publications - 6
Citations - 449
Yao Sen Ko is an academic researcher from Chiba University. The author has contributed to research in topics: Glutamate carboxypeptidase II & Glycine. The author has an hindex of 6, co-authored 6 publications receiving 405 citations.
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Journal ArticleDOI
Synthesis and biological evaluation of D-amino acid oxidase inhibitors.
Dana Ferraris,Bridget Duvall,Yao Sen Ko,Ajit G. Thomas,Camilo Rojas,Pavel Majer,Kenji Hashimoto,Takashi Tsukamoto +7 more
TL;DR: Oral administration of CBIO in conjunction with d-serine enhanced the plasma and brain levels of d-Serine in rats compared to the oral administration of d -serine alone.
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Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Pavel Majer,Paul F. Jackson,Greg Delahanty,Brian Grella,Yao Sen Ko,Weixing Li,Qun Liu,Maclin Keith M,Jana Polakova,Kathryn Ann Shaffer,Doris Stoermer,Dilrukshi Vitharana,Eric Wang,Anthony Zakrzewski,Camilo Rojas,Barbara S. Slusher,Krystyna M. Wozniak,Eric Burak,Tharin Limsakun,Takashi Tsukamoto +19 more
TL;DR: The most potent thiol-based inhibitor, 2-(3-mercaptopropyl)pentanedioic acid (IC(50) = 90 nM), was found to be orally bioavailable in rats and exhibited efficacy in an animal model of neuropathic pain following oral administration.
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Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs
Cyril Barinka,Klára Hlouchová,Klára Hlouchová,Miroslava Rovenska,Miroslava Rovenska,Pavel Majer,Miroslawa Dauter,Niyada Hin,Yao Sen Ko,Takashi Tsukamoto,Barbara S. Slusher,Jan Konvalinka,Jan Konvalinka,Jacek Lubkowski +13 more
TL;DR: The S1 pocket of GCPII could be accurately defined and analyzed for the first time, and the data indicate the importance of Asn519, Arg463, Arg534, and Arg536 for recognition of the penultimate substrate residues, as well as mechanistic explanation of G CPII preference for acidic dipeptides.
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Design and Synthesis of Poly ADP-ribose Polymerase-1 Inhibitors. 2. Biological Evaluation of Aza-5[H]-phenanthridin-6-ones as Potent, Aqueous-Soluble Compounds for the Treatment of Ischemic Injuries
Dana Ferraris,Yao Sen Ko,Thomas Pahutski,Rica Pargas Ficco,Larisa Serdyuk,Christina Alemu,Chadwick Bradford,Tiffany Chiou,Randall Hoover,Shirley Huang,Susan Lautar,Shi Liang,Qian Lin,May X.-C Lu,Maria Lourdes Mooney,Lisa Morgan,Yongzhen Qian,Scott B. Tran,Lawrence R. Williams,Qi Yi Wu,Jie Zhang,Yinong Zou,Vincent J. Kalish +22 more
TL;DR: Three compounds from this series demonstrated statistically significant protective effects in rat models of stroke and heart ischemia and were designed to improve the solubility and pharmacokinetic profiles for this series of PARP-1 inhibitors.
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Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors
Dana Ferraris,Yao Sen Ko,David Calvin,Tiffany Chiou,Susan Lautar,Bert E. Thomas,Krystyna M. Wozniak,Camilo Rojas,Vincent J. Kalish,Sergei Belyakov +9 more
TL;DR: The synthesis and structure-activity relationships (SAR) of two classes of electrophile-based dipeptidyl peptidase IV (DPP IV) inhibitors, the ketopyrrolidines and ketoazetidines, is discussed, demonstrating that the 2-thiazole, 2-benzothiazoles, and 2-pyridylketones are optimal S1' binding groups for potency against DPP IV.