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Yaowu Zheng
Researcher at Northeast Normal University
Publications - 63
Citations - 7439
Yaowu Zheng is an academic researcher from Northeast Normal University. The author has contributed to research in topics: Gene & Thrombin. The author has an hindex of 22, co-authored 58 publications receiving 7022 citations. Previous affiliations of Yaowu Zheng include University of California, San Francisco & United States Department of Veterans Affairs.
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Journal ArticleDOI
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Sylvaine Cases,Steven J. Smith,Yaowu Zheng,Heather M. Myers,Steven R. Lear,Eric Sande,Sabine Novak,Colin Collins,Carrie B. Welch,Aldons J. Lusis,Sandra K. Erickson,Robert V. Farese +11 more
TL;DR: An expressed sequence tag clone that shared regions of similarity with acyl CoA:cholesterol acyltransferase, an enzyme that also uses fatty acyl coA as a substrate was identified, which will greatly facilitate studies of cellular glycerolipid metabolism and its regulation.
Journal ArticleDOI
A dual thrombin receptor system for platelet activation
Mark L. Kahn,Yaowu Zheng,Wei Huang,Violeta Bigornia,Dewan Zeng,Stephen Moff,Robert V. Farese,Carmen Tam,Shaun R. Coughlin +8 more
TL;DR: It is reported that thrombin responses in platelets from PAR3-deficient mice were markedly delayed and diminished but not absent, and the identification of a two-receptor system for platelet activation byThrombin has important implications for the development of antithrombotic therapies.
Journal ArticleDOI
Protease-activated receptor 3 is a second thrombin receptor in humans.
Hiroaki Ishihara,Andrew J. Connolly,Dewan Zeng,Mark L. Kahn,Yaowu Zheng,Courtney Timmons,Tracy Tram,Shaun R. Coughlin +7 more
TL;DR: Cl cloning and characterization of a new human thrombin receptor, designated protease-activated receptor 3 (PAR3) is reported, which can mediate throm-bin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues, making it a candidate for the sought-after second platelet throm bin receptor.
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Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Rajita Pappu,Susan R. Schwab,Ivo Cornelissen,João Pereira,Jean B. Regard,Ying Xu,Eric Camerer,Yaowu Zheng,Yong Huang,Jason G. Cyster,Shaun R. Coughlin +10 more
TL;DR: Separate sources provide S1P to plasma and lymph to help lymphocytes exit the low-S1P environment of lymphoid organs, and disruption of compartmentalized S 1P signaling is a plausible mechanism by which S1p-receptor-1 agonists function as immunosuppressives.
Journal ArticleDOI
PAR3 is a cofactor for PAR4 activation by thrombin
Mayumi Nakanishi-Matsui,Yaowu Zheng,David J. Sulciner,Ethan J. Weiss,Matthew J. Ludeman,Shaun R. Coughlin +5 more
TL;DR: This article showed that mPAR3 does not itself mediate transmembrane signalling but instead functions as a cofactor for the cleavage and activation of mPAR4 by thrombin.